L
Luc Lebon
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 8
Citations - 464
Luc Lebon is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Heligmosomoides polygyrus & Microbiome. The author has an hindex of 5, co-authored 6 publications receiving 353 citations.
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Journal ArticleDOI
The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation
Mario M. Zaiss,Alexis Rapin,Luc Lebon,Lalit Kumar Dubey,Ilaria Mosconi,Kerstin Sarter,Alessandra Piersigilli,Alessandra Piersigilli,Laure Menin,Alan W. Walker,Alan W. Walker,Jacques Rougemont,Oonagh Paerewijck,Peter Geldhof,Kathleen McCoy,Andrew J. Macpherson,John Croese,Paul R. Giacomin,Alex Loukas,Tobias Junt,Benjamin J. Marsland,Nicola L. Harris +21 more
TL;DR: Chronic infection with the murine helminth Heligmosomoides polygyrus bakeri altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production and a similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.
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Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection.
Lalit Kumar Dubey,Luc Lebon,Ilaria Mosconi,Chen Ying Yang,Elke Scandella,Burkhard Ludewig,Sanjiv A. Luther,Nicola L. Harris +7 more
TL;DR: A role for type 2 inflammation in promoting stromal cell remodeling and de novo follicle formation by promoting B cell-stromal cell crosstalk is revealed.
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The Study of Host Immune Responses Elicited by the Model Murine Hookworms Nippostrongylus brasiliensis and Heligmosomoides polygyrus
Tiffany Bouchery,Beatrice Volpe,Kathleen Shah,Luc Lebon,Kara J. Filbey,Graham LeGros,Nicola L. Harris +6 more
TL;DR: A complete set of methods by which to investigate the natural progression of infection and the host immunological responses in the lung and intestine of H. brasiliensis and H. polygrus–infected mice are provided.
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Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection
Ilaria Mosconi,Lalit Kumar Dubey,Beatrice Volpe,Julia Esser-von Bieren,Mario M. Zaiss,Luc Lebon,Joanna Massacand,Nicola L. Harris +7 more
TL;DR: Data indicate that different degrees of Treg expansion and type 2 cytokine production occur within the PPs and MLN following infection with the intestinal helminth H. polygyrus bakeri and indicate that these organs exhibit differential responsesFollowing infection with intestinal helmineths.
Journal ArticleDOI
Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine.
TL;DR: Examination of the impact of experimental infection using the natural murine small intestinal helminth, Heligmosomoides polygyrus bakeri, revealed striking similarities in both the mucous and luminal bacterial communities along the entire small and large intestine.