T
Theodora-Dorita Tsourouktsoglou
Researcher at Francis Crick Institute
Publications - 7
Citations - 412
Theodora-Dorita Tsourouktsoglou is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Neutrophil extracellular traps & Myeloperoxidase. The author has an hindex of 4, co-authored 5 publications receiving 212 citations.
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Journal ArticleDOI
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation
Marie Toussaint,David A. Jackson,Dawid Swieboda,Anabel Guedán,Theodora-Dorita Tsourouktsoglou,Yee Man Ching,Coraline Radermecker,Heidi Makrinioti,Julia Aniscenko,Michael R. Edwards,Roberto Solari,Frédéric Farnir,Venizelos Papayannopoulos,Fabrice Bureau,Thomas Marichal,Sebastian L. Johnston +15 more
TL;DR: In a mouse model of allergic airway hypersensitivity, it is shown that rhinovirus infection triggers dsDNA release associated with the formation of neutrophil extracellular traps (NETs), known as NETosis, which contribute to the pathogenesis and may represent potential therapeutic targets of rhinOVirus-induced asthma exacerbations.
Journal ArticleDOI
Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4.
Theodora-Dorita Tsourouktsoglou,Annika Warnatsch,Marianna Ioannou,Dennis Hoving,Qian Wang,Venizelos Papayannopoulos +5 more
TL;DR: It is shown that histones, DNA, citrullination, and fragmentation synergize to drive inflammation below the histone cytotoxicity threshold, and chromatin blockade or PAD4 deficiency reduces atherosclerosis.
Journal ArticleDOI
Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps.
Tiffany Bouchery,Tiffany Bouchery,Mati Moyat,Mati Moyat,Javier Sotillo,Javier Sotillo,Solomon Silverstein,Beatrice Volpe,Gillian Coakley,Theodora-Dorita Tsourouktsoglou,Luke Becker,Kathleen Shah,Manuel Kulagin,Romain Guiet,Mali Camberis,Alfonso J Schmidt,Arne Seitz,Paul R. Giacomin,Graham Le Gros,Venizelos Papayannopoulos,Alex Loukas,Nicola L. Harris +21 more
TL;DR: Neutrophils depletion or NET inhibition altered larvae behavior and enhanced the number of adult worms following murine infection and a potential conserved mechanism of immune evasion are highlighted.
Journal ArticleDOI
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening
Marianna Ioannou,Dennis Hoving,Iker Valle Aramburu,Mia I. Temkin,Nathalia Moraes de Vasconcelos,Theodora-Dorita Tsourouktsoglou,Qian Wang,Stefan Boeing,Robert L. Goldstone,Spyros I. Vernardis,Vadim Demichev,Markus Ralser,Sascha David,K. Strahl,Christiane Bode,Venizelos Papayannopoulos +15 more
TL;DR: In this paper , the authors showed that neutrophil-derived myeloperoxidase attenuates sepsis by suppressing histone release in splenic macrophages.
Journal ArticleDOI
Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening
Marianna Ioannou,Dennis Hoving,Iker Valle Aramburu,Mia I. Temkin,Nathalia Moraes de Vasconcelos,Theodora-Dorita Tsourouktsoglou,Qian Wang,Stefan Boeing,Robert L. Goldstone,Spyros I. Vernardis,Vadim Demichev,Markus Ralser,Sascha David,K. Strahl,Christiane Bode,Venizelos Papayannopoulos +15 more
TL;DR: In this article , the authors showed that neutrophil-derived myeloperoxidase attenuates sepsis by suppressing histone release in splenic macrophages.