H
Henrique Veiga-Fernandes
Researcher at Instituto de Medicina Molecular
Publications - 74
Citations - 6624
Henrique Veiga-Fernandes is an academic researcher from Instituto de Medicina Molecular. The author has contributed to research in topics: Innate lymphoid cell & Immune system. The author has an hindex of 34, co-authored 69 publications receiving 5491 citations. Previous affiliations of Henrique Veiga-Fernandes include French Institute of Health and Medical Research & Great Ormond Street Hospital.
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Journal ArticleDOI
Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages.
Christoph S.N. Klose,Christoph S.N. Klose,Melanie Flach,Melanie Flach,Luisa Möhle,Leif Rogell,Leif Rogell,Leif Rogell,Thomas Hoyler,Thomas Hoyler,Karolina Ebert,Karolina Ebert,Carola Fabiunke,Carola Fabiunke,Dietmar Pfeifer,Veronika Sexl,Diogo Fonseca-Pereira,Rita G. Domingues,Henrique Veiga-Fernandes,Sebastian J. Arnold,Meinrad Busslinger,Ildiko Rita Dunay,Yakup Tanriver,Andreas Diefenbach +23 more
TL;DR: Interestingly, the CHILP differentiated into ILC2 and ILC3 lineages, but not into conventional natural killer cells that have been considered an ILC1 subset, presenting evidence for a new ILC lineage that protects barrier surfaces against intracellular infections.
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Response of naïve and memory CD8+ T cells to antigen stimulation in vivo.
TL;DR: It is found that initial naïve T cell priming resulted in cells expressing mutually exclusive effector functions, whereas memory T cells were multifunctional after reactivation, with each individual cell expressing two to three different effector function simultaneously.
Journal ArticleDOI
The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
Duncan M. Gascoyne,Elaine Long,Henrique Veiga-Fernandes,Henrique Veiga-Fernandes,Jasper de Boer,Owen Williams,Benedict Seddon,Mark Coles,Dimitris Kioussis,Hugh J.M. Brady +9 more
TL;DR: Overexpression of E4bp4 was sufficient to increase NK cell production from hematopoietic progenitor cells and acted in a cell-intrinsic manner 'downstream' of the interleukin 15 receptor (IL-15R and through the transcription factor Id2.
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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Vânia Cardoso,Julie Chesné,Hélder Ribeiro,Bethania García-Cassani,Tânia Carvalho,Tiffany Bouchery,Kathleen Shah,Nuno L. Barbosa-Morais,Nicola L. Harris,Henrique Veiga-Fernandes +9 more
TL;DR: It is shown that neuromedin U (NMU) in mice is a fast and potent regulator of type 2 innate immunity in the context of a functional neuron–ILC2 unit, and this work reveals that neuron–ilC2 cell units confer immediate tissue protection through coordinated neuroimmune sensory responses.
Journal ArticleDOI
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
Serge A. van de Pavert,Manuela Ferreira,Rita G. Domingues,Hélder Ribeiro,Rosalie Molenaar,Lara Moreira-Santos,Francisca F. Almeida,Sales Ibiza,Inês A. M. Barbosa,Gera Goverse,Carlos Labão-Almeida,Cristina Godinho-Silva,Tanja Konijn,Dennis P. M. Schooneman,Tom O’Toole,Mark R. Mizee,Yasmin Habani,Esther Haak,Fabio R. Santori,Dan R. Littman,Stefan Schulte-Merker,Elaine Dzierzak,J. Pedro Simas,Reina E. Mebius,Henrique Veiga-Fernandes +24 more
TL;DR: A molecular link between maternal nutrients and the formation of immune structures required for resistance to infection in the offspring is revealed and the size of secondary lymphoid organs and the efficiency of immune responses in the adult offspring are established.