N
Nicole M. Aiello
Researcher at University of Pennsylvania
Publications - 19
Citations - 6241
Nicole M. Aiello is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Pancreatic cancer & Epithelial–mesenchymal transition. The author has an hindex of 14, co-authored 19 publications receiving 4841 citations. Previous affiliations of Nicole M. Aiello include Princeton University.
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Journal ArticleDOI
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva,Nicole M. Aiello,Allyson J. Ocean,Swarnima Singh,Haiying Zhang,Basant Kumar Thakur,Basant Kumar Thakur,Annette Becker,Ayuko Hoshino,Milica Tesic Mark,Henrik Molina,Jenny Xiang,Tuo Zhang,Till Martin Theilen,Guillermo García-Santos,Caitlin Williams,Yonathan Ararso,Yujie Huang,Gonçalo Rodrigues,Tang-Long Shen,Knut Jørgen Labori,Inger Marie Bowitz Lothe,Elin H. Kure,Jonathan M. Hernandez,Alexandre Doussot,Saya H. Ebbesen,Paul M. Grandgenett,Michael A. Hollingsworth,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Robert E. Schwartz,Irina Matei,Héctor Peinado,Ben Z. Stanger,Jacqueline Bromberg,David Lyden,David Lyden +38 more
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Journal ArticleDOI
EMT and Dissemination Precede Pancreatic Tumor Formation
Andrew D. Rhim,Emily T. Mirek,Nicole M. Aiello,Anirban Maitra,Jennifer M. Bailey,Florencia McAllister,Maximilian Reichert,Gregory L. Beatty,Anil K. Rustgi,Robert H. Vonderheide,Steven D. Leach,Ben Z. Stanger +11 more
TL;DR: It is suggested that inflammation enhances cancer progression in part by facilitating EMT and entry into the circulation and tagged cells invaded and entered the bloodstream unexpectedly early, before frank malignancy could be detected by rigorous histologic analysis.
Journal ArticleDOI
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration
Nicole M. Aiello,Ravikanth Maddipati,Robert J. Norgard,David Balli,Jinyang Li,Salina Yuan,Taiji Yamazoe,Taylor A. Black,Amine Sahmoud,Emma E. Furth,Dafna Bar-Sagi,Ben Z. Stanger +11 more
TL;DR: Using a lineage-labeled mouse model of pancreatic ductal adenocarcinoma to study EMT in vivo, it is found that most tumors lose their epithelial phenotype through an alternative program involving protein internalization rather than transcriptional repression, resulting in a "partial EMT" phenotype.
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Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
Joyce V. Lee,Alessandro Carrer,Supriya Shah,Nathaniel W. Snyder,Shuanzeng Wei,Sriram Venneti,Andrew J. Worth,Zuo-Fei Yuan,Hee-Woong Lim,Shichong Liu,Ellen Jackson,Nicole M. Aiello,Naomi B. Haas,Timothy R. Rebbeck,Alexander R. Judkins,Kyoung-Jae Won,Lewis A. Chodosh,Benjamin A. Garcia,Ben Z. Stanger,Michael Feldman,Ian A. Blair,Kathryn E. Wellen +21 more
TL;DR: It is demonstrated that acetyl-CoA is dynamically regulated by glucose availability in cancer cells and that the ratio of acetyl -CoA:coenzyme A within the nucleus modulates global histone acetylation levels.
Journal ArticleDOI
Robust cellular reprogramming occurs spontaneously during liver regeneration
Kilangsungla Yanger,Yiwei Zong,Lara R. Maggs,Suzanne N. Shapira,Ravi Maddipati,Nicole M. Aiello,Swan N. Thung,Rebecca G. Wells,Linda E. Greenbaum,Ben Z. Stanger +9 more
TL;DR: It is reported that activation of Notch, a signaling pathway that mediates lineage segregation during liver development, is sufficient to reprogram hepatocytes into biliary epithelial cells (BECs) following injuries that provoke a biliary response.