C
Chao Lu
Researcher at Hong Kong Polytechnic University
Publications - 1056
Citations - 28372
Chao Lu is an academic researcher from Hong Kong Polytechnic University. The author has contributed to research in topics: Fiber Bragg grating & Optical fiber. The author has an hindex of 67, co-authored 979 publications receiving 23334 citations. Previous affiliations of Chao Lu include Columbia University & Institute for Infocomm Research Singapore.
Papers
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Journal ArticleDOI
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Maria E. Figueroa,Omar Abdel-Wahab,Chao Lu,Patrick S. Ward,Jay P. Patel,Alan Shih,Yushan Li,Neha Bhagwat,Aparna Vasanthakumar,Hugo F. Fernandez,Martin S. Tallman,Zhuoxin Sun,Kristy L. Wolniak,Justine K. Peeters,Wei Liu,Sung E. Choe,Valeria Fantin,Elisabeth Paietta,Bob Löwenberg,Jonathan D. Licht,Lucy A. Godley,Ruud Delwel,Peter J. M. Valk,Craig B. Thompson,Ross L. Levine,Ari Melnick +25 more
TL;DR: Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specificHypermethylation signature, suggesting a shared proleukemogenic effect.
Journal ArticleDOI
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu,Patrick S. Ward,Patrick S. Ward,Gurpreet S. Kapoor,Dan Rohle,Dan Rohle,Sevin Turcan,Omar Abdel-Wahab,Christopher R. Edwards,Raya Khanin,Maria E. Figueroa,Ari Melnick,Kathryn E. Wellen,Donald M. O'Rourke,Shelley L. Berger,Timothy A. Chan,Ross L. Levine,Ingo K. Mellinghoff,Ingo K. Mellinghoff,Craig B. Thompson +19 more
TL;DR: It is reported that 2HG-producing IDH mutants can prevent the histone demethylation that is required for lineage-specific progenitor cells to differentiate into terminally differentiated cells, and that inhibition of histone methylation can be sufficient to block the differentiation of non-transformed cells.
Journal ArticleDOI
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan,Daniel Rohle,Daniel Rohle,Anuj Goenka,Logan A. Walsh,Fang Fang,Emrullah Yilmaz,Carl Campos,Armida W. M. Fabius,Chao Lu,Chao Lu,Patrick S. Ward,Patrick S. Ward,Craig B. Thompson,Andrew Kaufman,Olga A. Guryanova,Ross L. Levine,Adriana Heguy,Agnes Viale,Luc G. T. Morris,Jason T. Huse,Ingo K. Mellinghoff,Ingo K. Mellinghoff,Timothy A. Chan,Timothy A. Chan +24 more
TL;DR: It is demonstrated that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), establishes CIMP by remodelling the methylome, and the epigenomic alterations resulting from mutant IDH1 activate key gene expression programs, characterize G-CIMP-positive proneural glioblastomas but not other gliOBlastomas, and are predictive of improved survival.
Journal ArticleDOI
Metabolic Regulation of Epigenetics
Chao Lu,Craig B. Thompson +1 more
TL;DR: Recent progress in understanding the molecular connection between metabolism and epigenetic modifications of chromatin implicated in a variety of diseases including cancer is summarized.
Journal ArticleDOI
Hypoxia Induces Production of L-2-Hydroxyglutarate
Andrew M. Intlekofer,Raymond G. DeMatteo,Sriram Venneti,Lydia W.S. Finley,Chao Lu,Alexander R. Judkins,Ariën S. Rustenburg,Patrick B. Grinaway,John D. Chodera,Justin R. Cross,Craig B. Thompson +10 more
TL;DR: It is reported that under conditions of oxygen limitation, mammalian cells selectively produce L-2HG via enzymatic reduction of α-KG through promiscuous substrate usage primarily by lactate dehydrogenase A (LDHA).