K
Katrin Kerl
Researcher at University of Zurich
Publications - 109
Citations - 2660
Katrin Kerl is an academic researcher from University of Zurich. The author has contributed to research in topics: Lymphoma & Melanoma. The author has an hindex of 25, co-authored 106 publications receiving 2242 citations. Previous affiliations of Katrin Kerl include Charles University in Prague & Medical University of Graz.
Papers
More filters
Journal ArticleDOI
Subcutaneous, blastic natural killer (NK), NK/T-cell, and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic, and molecular study of 50 patients.
Cesare Massone,Andreas Chott,Dieter Metze,Katrin Kerl,Luigi Citarella,Esmeralda Vale,Helmut Kerl,Lorenzo Cerroni +7 more
TL;DR: With the exception of SPTCL, analysis of follow-up data from patients with subcutaneous, blastic natural killer (NK), NK/T-cell, or other non–mycosis fungoides cytotoxic T-cell lymphomas of the skin showed that these groups of lymphomas are characterized by an aggressive course, regardless of the diagnostic category.
Journal ArticleDOI
The Nlrp3 inflammasome regulates acute graft-versus-host disease
Dragana Jankovic,Jayanthi Ganesan,Michael Bscheider,Natalie Stickel,Felix C. Weber,Greta Guarda,Marie Follo,Dietmar Pfeifer,Aubry Tardivel,Kristina Ludigs,Abdellatif Bouazzaoui,Katrin Kerl,Julius C. Fischer,Tobias Haas,Annette Schmitt-Gräff,Anand Manoharan,Leonard Müller,Jürgen Finke,Stefan F. Martin,Oliver Gorka,Christian Peschel,Jürgen Ruland,Marco Idzko,Justus Duyster,Ernst Holler,Lars E. French,Hendrik Poeck,Emmanuel Contassot,Robert Zeiser +28 more
TL;DR: Conditioning therapies before transplantation induce the release of uric acid, which triggers the NLRP3 inflammasome and IL-1β production contributing to graft-versus-host disease.
Journal ArticleDOI
IL-1β Drives Inflammatory Responses to Propionibacterium acnes In Vitro and In Vivo
Magdalena Kistowska,Samuel Gehrke,Dragana Jankovic,Katrin Kerl,Antonia Fettelschoss,Laurence Feldmeyer,Gabriele Fenini,Antonios G.A. Kolios,Alexander A. Navarini,Ruta Ganceviciene,Jürgen Schauber,Emmanuel Contassot,Lars E. French +12 more
TL;DR: Findings show that the commensal P. acnes-by activating the inflammasome-can trigger an innate immune response in the skin, thus establishing the NLRP3-inflam Masome and IL-1β as possible therapeutic targets in acne.
Journal ArticleDOI
TNF-α and IFN-γ Are Potential Inducers of Fas-Mediated Keratinocyte Apoptosis through Activation of Inducible Nitric Oxide Synthase in Toxic Epidermal Necrolysis
Isabelle Viard-Leveugle,Olivier Gaide,Dragana Jankovic,Laurence Feldmeyer,Katrin Kerl,Chris Pickard,Stéphanie Roques,Peter S. Friedmann,Emmanuel Contassot,Lars E. French +9 more
TL;DR: It is suggested that T-lymphocyte activation by drugs in TEN patients may indirectly lead to FasL-mediated keratinocyte apoptosis, via a molecular bridge involving TNF-α, IFN-γ, and iNOS.
Journal ArticleDOI
Tumour hypoxia promotes melanoma growth and metastasis via High Mobility Group Box-1 and M2-like macrophages
Roman Huber,Barbara Meier,Atsushi Otsuka,Gabriele Fenini,Takashi K. Satoh,Samuel Gehrke,Daniel S. Widmer,Mitchell P. Levesque,Joanna Mangana,Katrin Kerl,Christoffer Gebhardt,Hiroko Fujii,Chisa Nakashima,Yumi Nonomura,Kenji Kabashima,Reinhard Dummer,Emmanuel Contassot,Lars E. French +17 more
TL;DR: This work shows that the damage-associated molecular pattern High-Mobility Group Box 1 protein (HMGB1) is released by melanoma tumour cells as a consequence of hypoxia and promotes M2-like tumour-associated macrophage accumulation and an IL-10 rich milieu within the tumour.