K
Katsutoshi Goto
Researcher at University of Tsukuba
Publications - 231
Citations - 31742
Katsutoshi Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Endothelin receptor. The author has an hindex of 63, co-authored 228 publications receiving 31015 citations. Previous affiliations of Katsutoshi Goto include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane
Tatsuya Sawamura,Osamu Shinmi,Naoya Kishi,Yoshiki Sugita,Masashi Yanagisawa,Katsutoshi Goto,Tomoh Masaki,Sadao Kimura +7 more
TL;DR: The finding that neither thiorphan nor bacitracin affected the conversion of endogenously synthesized big ET-1 in cultured endothelial cells is concluded, suggesting that physiologically relevant ECE found in the endothelial Cells is more similar to M1 than to M2.
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Endothelin-1 mediates regional blood flow during and after pulmonary operations.
Masataka Onizuka,Takashi Miyauchi,Kiyofumi Mitsui,Nobuhiro Suzuki,Tomoh Masaki,Katsutoshi Goto,Motokazu Hori +6 more
TL;DR: The present findings provide a novel hypothesis that the preferential release of endothelin-1 from the peripheral vasculature of the forearm may partly contribute to a compensatory response to surgical stress, for example, the reduction of local blood flow in nonvital organs so as to increase theBlood flow in vital organs.
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A combination of oral endothelin-areceptor antagonist and oral prostacyclinanalogue is superior to each drug alone inameliorating pulmonary hypertension in rats
Michihiko Ueno,Takashi Miyauchi,Satoshi Sakai,Rikako Yamauchi-Kohno,Katsutoshi Goto,Iwao Yamaguchi +5 more
TL;DR: The combination of an oral ETA receptor antagonist and an oral prostacyclin (PGI2) analogue is superior to the single use of each drug alone for treating pulmonary hypertension (PH) as mentioned in this paper.
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Endothelin receptor antagonist reverses decreased NO system in the kidney in vivo during exercise
Seiji Maeda,Takashi Miyauchi,Motoyuki Iemitsu,Takumi Tanabe,Katsutoshi Goto,Iwao Yamaguchi,Mitsuo Matsuda +6 more
TL;DR: It is provided a possibility that the exercise-induced increase in production of ET-1 in the kidney causes a decrease in blood flow in the kidneys through two pathways, i.e., vasoconstrictive action and the action of attenuating NO production.
Journal Article
Intramural nerve-mediated inotropic responses of left atria of rats and guinea pigs: demonstration of alpha adrenergic and nonadrenergic noncholinergic responses in guinea pigs.
TL;DR: It is demonstrated that TNS excitated adrenergic, cholinergic and nonadrenergic noncholinergic nerves in guinea pig left atria.