K
Katsutoshi Goto
Researcher at University of Tsukuba
Publications - 231
Citations - 31742
Katsutoshi Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Endothelin receptor. The author has an hindex of 63, co-authored 228 publications receiving 31015 citations. Previous affiliations of Katsutoshi Goto include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Akihiro Yamanaka,Carsten T. Beuckmann,Jon T. Willie,Junko Hara,Natsuko Tsujino,Michihiro Mieda,Makoto Tominaga,Ken-ichi Yagami,Fumihiro Sugiyama,Katsutoshi Goto,Masashi Yanagisawa,Masashi Yanagisawa,Takeshi Sakurai +12 more
TL;DR: It is demonstrated that hypothalamic orexin neurons monitor indicators of energy balance and mediate adaptive augmentation of arousal in response to fasting, indicating that orexIn neurons provide a crucial link between energy Balance and arousal.
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Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.
Masashi Yanagisawa,Akihiro Inoue,Tomohisa Ishikawa,Yoshitoshi Kasuya,Sadao Kimura,S Kumagaye,Kazunori Nakajima,Takashi Watanabe,Shin Ichi Sakakibara,Katsutoshi Goto +9 more
TL;DR: This synthetic peptide had potent vasoconstrictor activity in the rat aortic strip and in perfused rat heart and a characteristically long-lasting in vivo pressor activity by intraaortic bolus injection in the conscious rat.
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Calcitonin gene-related peptide acts as a novel vasodilator neurotransmitter in mesenteric resistance vessels of the rat
TL;DR: Pharmacological evidence for the existence of nonadrenergic, non-cholinergic (NANC) vasodilator nerves in the mesenteric resistance vessel of the rat is presented and CGRP is shown to play a role in control of the total peripheral resistance of systemic circulation through a local reflex mechanism.
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Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.
Takeshi Sakurai,Ruby Nagata,Akihiro Yamanaka,Hiroko Kawamura,Natsuko Tsujino,Yo Muraki,Haruaki Kageyama,Satoshi Kunita,Satoru Takahashi,Katsutoshi Goto,Yoshimasa Koyama,Seiji Shioda,Masashi Yanagisawa +12 more
TL;DR: It is revealed that orexin neurons receive input from several brain areas, including the amygdala, basal forebrain cholinergic neurons, GABAergic neuron in the preoptic area, and serotonergic neurons in the median/paramedian raphe nuclei.
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Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.
TL;DR: The rationale for ET-induced vasoconstriction is reviewed, particularly from the standpoint of molecular and cellular aspects and the importance of ET in the pathogenesis of hypertension and vasospasm is reviewed.