K
Katsutoshi Goto
Researcher at University of Tsukuba
Publications - 231
Citations - 31742
Katsutoshi Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Endothelin receptor. The author has an hindex of 63, co-authored 228 publications receiving 31015 citations. Previous affiliations of Katsutoshi Goto include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats
Kazuhiko Matsumaru,Hiromasa Kashimura,Mahmudul Hassan,Akira Nakahara,Katsutoshi Goto,Hisayuki Fukutomi,Hiroshi Muto,Naomi Tanaka +7 more
TL;DR: The prevention of gastric mucosal damage by an ECE inhibitor indicates that endogenous ET-1 may play an important role in the pathogenesis of indomethacin-induced gastricucosal damage.
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Alterations in gene expressions encoding preproET-1 and NOS in pulmonary tissue in endotoxemic rats.
Sohel Zaedi,Subrina Jesmin,Seiji Maeda,Nobutake Shimojo,Iwao Yamaguchi,Katsutoshi Goto,Takashi Miyauchi +6 more
TL;DR: Time-dependent onset of features of acute lung injury, such as the infiltration of inflammatory cells and thickening of alveolar septa, were seen in rats that received LPS, and the increased expression of NOS may result in excess NO production and may also play a role in the pulmonary complications of endotoxemia.
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Abnormal neurohumoral responses to exercise in patients with heart disease: inhibition of an increase in endothelin-1 production during exercise.
Shiro Ishikawa,Takashi Miyauchi,Michihiko Ueno,Kouichi Sagawa,Satoshi Sakai,Hiroya Ushinohama,Hideaki Kado,Hiroshi Sunagawa,Katsutoshi Goto,Yasuro Sugishita,Sunao Honda +10 more
TL;DR: It is suggested thatET-1 plays an important role in redistribution of blood during exercise, and the possibility that failure of an increase in ET-1 production results in exercise intolerance in patients with heart disease is proposed.
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Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes.
Nobutake Shimojo,Takashi Miyauchi,Motoyuki Iemitsu,Yoko Irukayama-Tomobe,Seiji Maeda,Takeshi Ohkubo,Yukihisa Tanaka,Katsutoshi Goto,Iwao Yamaguchi +8 more
TL;DR: It is suggested that medium-chain triglyceride application to spontaneously hypertensive rats improves decreased cardiac function and cardiac hypertrophy without affecting blood pressure and myocardial mRNA expression of molecular markers.
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Alterations of gene expressions of preproET-1 and ET receptors in brains of endotoxemic Sprague-Dawley rats.
Nobutake Shimojo,Subrina Jesmin,Sohel Zaedi,Seiji Maeda,Satoshi Gando,Iwao Yamaguchi,Katsutoshi Goto,Takashi Miyauchi +7 more
TL;DR: It is reported for the first time that expressions of the genes encoding ET-1 and ET receptors are altered in the endotoxemic brain and that these alterations are time-dependent in SD rats.