K
Katsutoshi Goto
Researcher at University of Tsukuba
Publications - 231
Citations - 31742
Katsutoshi Goto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Endothelin 1 & Endothelin receptor. The author has an hindex of 63, co-authored 228 publications receiving 31015 citations. Previous affiliations of Katsutoshi Goto include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT1A Receptor
Yo Muraki,Akihiro Yamanaka,Natsuko Tsujino,Thomas S. Kilduff,Katsutoshi Goto,Takeshi Sakurai +5 more
TL;DR: 5-HT hyperpolarizes orexin neurons through the 5-HT1A receptor and subsequent activation of the GIRK and that this inhibitory serotonergic input to the orexIn neurons is likely to be important for the physiological regulation of this neuropeptide system.
Journal ArticleDOI
Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1.
Sadao Kimura,Yoshitoshi Kasuya,Tatsuya Sawamura,Osamu Shinmi,Yoshiki Sugita,Masashi Yanagisawa,Katsutoshi Goto,Tomoh Masaki +7 more
TL;DR: Results indicate that the conversion of bigET-1 to “mature” ET-1 is essential for the expression of the full vasoconstrictor activity, suggesting the physiological importance of the unusual proteolytic processing catalyzed by the putative “ET converting enzyme.”
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Endothelin receptor is coupled to phospholipase C via a pertussis toxin-insensitive guanine nucleotide-binding regulatory protein in vascular smooth muscle cells.
Yoh Takuwa,Yoshitoshi Kasuya,Noriko Takuwa,Michiyo Kudo,Masashi Yanagisawa,Katsutoshi Goto,Tomoh Masaki,Kamejiro Yamashita +7 more
TL;DR: Results indicate that the receptor for ET is coupled to phospholipase C via a guanine nucleotide-binding regulatory protein which is distinct from the pertussis toxin substrate in A-10 cells.
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Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins.
Yun Zhu,Yoshihiro Miwa,Akihiro Yamanaka,Toshihiko Yada,Megumi Shibahara,Yoichiro Abe,Takeshi Sakurai,Katsutoshi Goto +7 more
TL;DR: It is found that a phospholipase C (PLC)-inhibitor, U73122, inhibits orexin-mediated neuronal activation, but PTX showed no effect on it, which suggests that although OX2R couples to multiple G-proteins, activation of neurons by orexins through Ox2R is mediated via a PTX-insensitive, PLC dependent pathway.
Journal ArticleDOI
Endothelin acts in feline and canine cerebral arteries from the adventitial side.
Tatsuo Mima,Masashi Yanagisawa,Taku Shigeno,Akira Saito,Katsutoshi Goto,Kintomo Takakura,Tomoh Masaki +6 more
TL;DR: The long-lasting nature of endothelin-induced constriction of the cerebral arteries in vivo suggests that the peptide might be involved in the pathogenesis of cerebral vasospasm, possibly due to the presence of the blood-arterial wall barrier.