L
Lisa E. Wagar
Researcher at Stanford University
Publications - 32
Citations - 2337
Lisa E. Wagar is an academic researcher from Stanford University. The author has contributed to research in topics: Population & Major histocompatibility complex. The author has an hindex of 18, co-authored 28 publications receiving 1489 citations. Previous affiliations of Lisa E. Wagar include University of Ontario Institute of Technology & University of California, Irvine.
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Journal ArticleDOI
Identifying specificity groups in the T cell receptor repertoire
Jacob Glanville,Huang Huang,Allison Nau,Olivia Hatton,Lisa E. Wagar,Florian Rubelt,Xuhuai Ji,Arnold Han,Sheri M. Krams,Christina Pettus,Nikhil Haas,Cecilia S. Lindestam Arlehamn,Alessandro Sette,Scott D. Boyd,Thomas J. Scriba,Olivia M. Martinez,Mark M. Davis +16 more
TL;DR: The GLIPH algorithm can analyse large numbers of TCR sequences and define TCR specificity groups shared by TCRs and individuals, which should greatly accelerate the analysis of T cell responses and expedite the identification of specific ligands.
Journal ArticleDOI
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
Ameen A. Salahudeen,Ameen A. Salahudeen,Shannon S. Choi,Arjun Rustagi,Junjie Zhu,Vincent van Unen,Sean M. de la O,Ryan A. Flynn,Mar Margalef-Català,António J. M. Santos,Jihang Ju,Arpit Batish,Tatsuya Usui,Grace X.Y. Zheng,Caitlin E. Edwards,Lisa E. Wagar,Vincent C. Luca,Benedict Anchang,Monica Nagendran,Khanh Nguyen,Daniel J. Hart,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Pehr B. Harbury,Jeffrey S. Glenn,K. Christopher Garcia,Mark M. Davis,Ralph S. Baric,Chiara Sabatti,Manuel R. Amieva,Catherine A. Blish,Tushar J. Desai,Calvin J. Kuo +34 more
TL;DR: A facile in vitro organoid model of human distal lung infections, including COVID-19-associated pneumonia, is established and a long-term culture method for organoids derived from single adult human lung cells is used to identify progenitor cells and study SARS-CoV-2 infection.
Journal ArticleDOI
High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization.
Marcela Alcántara-Hernández,Rebecca Leylek,Lisa E. Wagar,Edgar G. Engleman,Tibor Keler,M. Peter Marinkovich,M. Peter Marinkovich,Mark M. Davis,Garry P. Nolan,Juliana Idoyaga +9 more
TL;DR: A multiparametric phenotypic characterization and unbiased analysis of human dendritic cells subsets in blood, tonsil, spleen, and skin reveals interindividual heterogeneity among DC subsets, especially cDC2s and profiles the heterogeneity of human DC subset among individuals and tissues, providing comprehensive insights for the development of DC‐based therapeutics.
Journal ArticleDOI
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens
Michael S. Khodadoust,Niclas Olsson,Lisa E. Wagar,Ole Audun Werner Haabeth,Binbin Chen,Kavya Swaminathan,Keith Rawson,Chih Long Liu,David F. Steiner,Peder Lund,Samhita Rao,Lichao Zhang,Caleb D. Marceau,Henning Stehr,Aaron M. Newman,Debra K. Czerwinski,Victoria Carlton,Martin Moorhead,Malek Faham,Holbrook E Kohrt,Jan E. Carette,Michael R. Green,Mark M. Davis,Ronald Levy,Joshua E. Elias,Ash A. Alizadeh +25 more
TL;DR: This work discovers neoantigens in human mantle-cell lymphomas by using an integrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major histocompatibility complex (MHC) class I and class II molecules.
Journal ArticleDOI
Predicting HLA class II antigen presentation through integrated deep learning
Binbin Chen,Michael S. Khodadoust,Niclas Olsson,Lisa E. Wagar,Ethan Fast,Chih Long Liu,Yagmur Muftuoglu,Brian Sworder,Maximilian Diehn,Ronald Levy,Mark M. Davis,Mark M. Davis,Joshua E. Elias,Russ B. Altman,Ash A. Alizadeh +14 more
TL;DR: A neural network trained on diverse datasets improves prediction of HLA class II epitope presentation, and across independent cancer neoantigen studies, peptides with high MARIA scores are more likely to elicit strong CD4+ T cell responses.