K
Kay Hamacher
Researcher at Technische Universität Darmstadt
Publications - 131
Citations - 2281
Kay Hamacher is an academic researcher from Technische Universität Darmstadt. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 22, co-authored 117 publications receiving 1879 citations. Previous affiliations of Kay Hamacher include University of California, San Diego & Technical University of Dortmund.
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Journal ArticleDOI
Structure and Anonymity of the Bitcoin Transaction Graph
TL;DR: Dynamical effects of which some increase anonymity while others decrease it are found, and several parameters of the Bitcoin transaction graph seem to have become stationary over the last 12–18 months.
Journal ArticleDOI
Stochastic Tunneling Approach for Global Minimization of Complex Potential Energy Landscapes
Wolfgang Wenzel,Kay Hamacher +1 more
TL;DR: In this paper, a stochastic technique for the global optimization of complex potential energy surfaces (PES) is proposed, which avoids the freezing problem of simulated annealing by allowing the dynamical process to tunnel energetically inaccessible regions of the PES by way of a dynamically adjusted nonlinear transformation of the original PES.
Journal ArticleDOI
DOCKTITE-a highly versatile step-by-step workflow for covalent docking and virtual screening in the molecular operating environment.
TL;DR: DOCKTITE, a highly versatile workflow for covalent docking in the Molecular Operating Environment (MOE) combining automated warhead screening, nucleophilic side chain attachment, pharmacophore-based docking, and a novel consensus scoring approach is presented.
Journal ArticleDOI
HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond
Carla Marini,Alessandro Porro,Agnès Rastetter,Carine Dalle,Ilaria Rivolta,Daniel Bauer,Renske Oegema,Caroline Nava,Elena Parrini,Davide Mei,Catherine Mercer,Radhika Dhamija,Chelsea Chambers,Christine Coubes,Julien Thevenon,Paul Kuentz,Sophie Julia,Laurent Pasquier,Christèle Dubourg,Wilfrid Carré,Anna Rosati,Federico Melani,Tiziana Pisano,Maria Giardino,A. Micheil Innes,Yves Alembik,Sophie Scheidecker,Manuela Santos,Sonia Figueiroa,Cristina Garrido,Carlo Fusco,Daniele Frattini,Carlotta Spagnoli,Anna Binda,Tiziana Granata,Francesca Ragona,Elena Freri,Silvana Franceschetti,Laura Canafoglia,Barbara Castellotti,Cinzia Gellera,Raffaella Milanesi,Maria Margherita Mancardi,Damien R Clark,Fernando Kok,Katherine L. Helbig,Shoji Ichikawa,Laurie S. Sadler,Jana Neupauerová,Petra Laššuthová,Katalin Sterbova,Annick Laridon,Eva H. Brilstra,Bobby P. C. Koeleman,Johannes R. Lemke,Federico Zara,Pasquale Striano,Julie Soblet,Guillaume Smits,Nicolas Deconinck,Andrea Barbuti,Dario DiFrancesco,Eric LeGuern,Renzo Guerrini,Bina Santoro,Kay Hamacher,Gerhard Thiel,Anna Moroni,Jacopo C. DiFrancesco,Christel Depienne +69 more
TL;DR: The results considerably expand the clinical spectrum related to HCN1 variants to include common generalized epilepsy phenotypes and further illustrate howHCN1 has a pivotal function in brain development and control of neuronal excitability.
Journal ArticleDOI
Next-level riboswitch development-implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch
Adrien Boussebayle,Daniel Torka,Sandra Ollivaud,Johannes Braun,Cristina Bofill-Bosch,Max Dombrowski,Florian Groher,Kay Hamacher,Beatrix Suess +8 more
TL;DR: This work developed a new paromomycin-binding synthetic riboswitch that binds parommycin with a KD of 20 nM and can discriminate between closely related molecules both in vitro and in vivo, and broadens the spectrum of existing RNA regulators.