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Christel Depienne

Researcher at University of Paris

Publications -  175
Citations -  11249

Christel Depienne is an academic researcher from University of Paris. The author has contributed to research in topics: Epilepsy & Medicine. The author has an hindex of 54, co-authored 149 publications receiving 9038 citations. Previous affiliations of Christel Depienne include University of Copenhagen & French Alternative Energies and Atomic Energy Commission.

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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

Phil Lee, +606 more
- 12 Dec 2019 - 
TL;DR: Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes.
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Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

Claire S. Leblond, +59 more
- 04 Sep 2014 - 
TL;DR: Mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment and the clinical relevance of these genes remains to be ascertained.
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Sporadic Infantile Epileptic Encephalopathy Caused by Mutations in PCDH19 Resembles Dravet Syndrome but Mainly Affects Females

Christel Depienne, +29 more
- 13 Feb 2009 - 
TL;DR: The identification of an affected mosaic male strongly supports the hypothesis that cellular interference is the pathogenic mechanism of Dravet syndrome and suggests that PCDH19 plays a major role in epileptic encephalopathies, with a clinical spectrum overlapping that of DS.
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Spectrum of SCN1A gene mutations associated with Dravet syndrome: analysis of 333 patients

Christel Depienne, +13 more
- 17 Oct 2008 - 
TL;DR: This mutation spectrum, including whole gene deletions, argues in favour of haploinsufficiency as the main mechanism responsible for Dravet syndrome.