K
Kazuhiro Sogawa
Researcher at Tohoku University
Publications - 93
Citations - 7018
Kazuhiro Sogawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Gene & Complementary DNA. The author has an hindex of 40, co-authored 93 publications receiving 6795 citations. Previous affiliations of Kazuhiro Sogawa include National Institute of Radiological Sciences & University of Tokyo.
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Journal ArticleDOI
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
Masatsugu Ema,Shinichiro Taya,Noboru Yokotani,Kazuhiro Sogawa,Youichi Matsuda,Yoshiaki Fujii-Kuriyama +5 more
TL;DR: The high expression level of HLF mRNA in the O2 delivery system of developing embryos and adult organs suggests that in a normoxic state, HLF regulates gene expression of VEGF, various glycolytic enzymes, and others driven by the HRE sequence, and may be involved in development of blood vessels and the tubular system of lung.
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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.
Masatsugu Ema,Kiichi Hirota,Junsei Mimura,Hisaku Abe,Junji Yodoi,Kazuhiro Sogawa,Lorenz Poellinger,Yoshiaki Fujii-Kuriyama +7 more
TL;DR: Transfection analysis using fusion genes of GAL4DBD with various fragments of the two factors delineated two transcription activation domains which are inducible in response to hypoxia and are localized in the C‐terminal half of HIF1α.
Journal ArticleDOI
cDNA cloning and structure of mouse putative Ah receptor
Masatsugu Ema,Kazuhiro Sogawa,Norimichi Watanabe,Y. Chujoh,Natsuki Matsushita,Osamu Gotoh,Yoshihiko Funae,Yoshiaki Fujii-Kuriyama +7 more
TL;DR: Mouse cDNA clones for a putative Ah receptor have been isolated from a cDNA library of mRNA from Hepa-1 cells by an oligonucleotide probe produced by PCR with a pair of primers which was synthesized according to the reported N-terminal sequence of 26 amino acids.
Journal ArticleDOI
Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene.
H. Imataka,Kazuhiro Sogawa,Ken Ichi Yasumoto,Yasuo Kikuchi,K. Sasano,Akira Kobayashi,M. Hayami,Yoshiaki Fujii-Kuriyama +7 more
TL;DR: RNA blot analysis showed that mRNAs for BTEB and Sp1 were expressed in all tissues tested, but their concentrations varied independently in tissues, while the former mRNA was rich in the brain, kidney, lung and testis, whereas the latter was relatively abundant in the thymus and spleen.
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cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).
Ken ichiro Hirose,Masanobu Morita,Masatsugu Ema,Junsei Mimura,Hiroshi Hamada,Hideta Fujii,Saijo Yukio,Osamu Gotoh,Kazuhiro Sogawa,Yoshiaki Fujii-Kuriyama +9 more
TL;DR: In this article, the authors isolated mouse cDNA clones (Arnt2) that are highly similar to but distinct from the aryl hydrocarbon receptor (AhR) nuclear translocator (ArNT), and the composite cDNA covered a 2,443-bp sequence consisting of a putative 2,136-bp open reading frame encoding a polypeptide of 712 amino acids.