K
Kazuhiro Suzuki
Researcher at Osaka University
Publications - 42
Citations - 4068
Kazuhiro Suzuki is an academic researcher from Osaka University. The author has contributed to research in topics: Semaphorin & Immune system. The author has an hindex of 26, co-authored 42 publications receiving 3580 citations. Previous affiliations of Kazuhiro Suzuki include Japan Agency for Medical Research and Development & National Presto Industries.
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Journal ArticleDOI
Semaphorins and their receptors in immune cell interactions
TL;DR: The present knowledge of the function of semaphorins and their receptors in the immune system is reviewed, including the most recent advances in this field.
Journal ArticleDOI
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Atsushi Kumanogoh,Satoko Marukawa,Kazuhiro Suzuki,Noriko Takegahara,Chie Watanabe,Ewe Seng Ch'ng,Isao Ishida,Harutoshi Fujimura,Saburo Sakoda,Kanji Yoshida,Hitoshi Kikutani +10 more
TL;DR: It is reported that the class IV semaphorin Sema4A, which is expressed in dendritic cells and B cells, enhances the in vitro activation and differentiation of T cells and the in vivo generation of antigen-specific T cells.
Journal ArticleDOI
Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin
Kazuhiro Suzuki,Tatsusada Okuno,Midori Yamamoto,R. Jeroen Pasterkamp,Noriko Takegahara,Hyota Takamatsu,Tomoe Kitao,Junichi Takagi,Paul D. Rennert,Alex L. Kolodkin,Atsushi Kumanogoh,Hitoshi Kikutani +11 more
TL;DR: It is shown that Sema7A, which is expressed on activated T cells, stimulates cytokine production in monocytes and macrophages through α1β1 integrin as a component of the immunological synapse, and is critical for the effector phase of the inflammatory immune response.
Journal ArticleDOI
Visualizing B cell capture of cognate antigen from follicular dendritic cells
TL;DR: It is established that FDCs can serve as sites of B cell antigen capture, with their prolonged display time ensuring that even rare B cells have the chance of antigen encounter, and they suggest possible information transfer from antigen-presenting cell to B cell.
Journal ArticleDOI
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Noriko Takegahara,Hyota Takamatsu,Toshihiko Toyofuku,Tohru Tsujimura,Tatsusada Okuno,Kazunori Yukawa,Masayuki Mizui,Midori Yamamoto,Durbaka V. R. Prasad,Kazuhiro Suzuki,Masaru Ishii,Kenta Terai,Masayuki Moriya,Yuji Nakatsuji,Saburo Sakoda,Shintaro Sato,Shizuo Akira,Kiyoshi Takeda,Masanori Inui,Toshiyuki Takai,Masahito Ikawa,Masaru Okabe,Atsushi Kumanogoh,Hitoshi Kikutani +23 more
TL;DR: It is shown that plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12, that presents a novel signalling mechanism for exerting the pleiotropic functions of semaphors.