K
Kazuo Tsubota
Researcher at Keio University
Publications - 1421
Citations - 57308
Kazuo Tsubota is an academic researcher from Keio University. The author has contributed to research in topics: Cornea & Visual acuity. The author has an hindex of 105, co-authored 1379 publications receiving 48991 citations. Previous affiliations of Kazuo Tsubota include Chiba University & Showa University.
Papers
More filters
Journal ArticleDOI
Design and conduct of clinical trials: Report of the clinical trials subcommittee of the international Dry Eye WorkShop (2007)
Kazuo Tsubota,Penny Ashell,Murat Dogru,Desmond Fonn,Gary N. Foulks,Debra A. Schaumberg,Oliver D. Schein,Hitoshi Watanabe +7 more
TL;DR: This report identifies peculiarities of dry eye disease that complicate clinical trial design, such as the lack of correlation of signs and symptoms, as well as the likelihood of control interventions having a lubricant (placebo) effect.
Journal ArticleDOI
Sleep and mood disorders in dry eye disease and allied irritating ocular diseases.
Masahiko Ayaki,Motoko Kawashima,Kazuno Negishi,Taishiro Kishimoto,Masaru Mimura,Kazuo Tsubota +5 more
TL;DR: It is demonstrated that sleep quality in patients with DED is significantly worse than in patientsWith other irritating ocular surface diseases and it is correlated with the severity of DED.
Journal ArticleDOI
Hyaluronic acid-CD44 interaction mediates the adhesion of lymphocytes by amniotic membrane stroma.
TL;DR: HA in AM stroma may play an important role in the entrapment of inflammatory cells including lymphocytes when used as a patch in ocular surface disease.
Journal ArticleDOI
Functional MRI of brain activation by eye blinking.
TL;DR: In severe dry eye, blink-inhibition strongly activated the visual cortex even after irritation due to corneal desiccation was removed by topical anesthesia and the blinking process, especially the rate, appears to be controlled in the orbitofrontal cortex.
Journal ArticleDOI
Role of bile acids in the regulation of the metabolic pathways.
Hiroki Taoka,Yoko Yokoyama,Kohkichi Morimoto,Naho Kitamura,Tatsuya Tanigaki,Yoko Takashina,Kazuo Tsubota,Mitsuhiro Watanabe +7 more
TL;DR: This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome.