K
Kazuo Tsubota
Researcher at Keio University
Publications - 1421
Citations - 57308
Kazuo Tsubota is an academic researcher from Keio University. The author has contributed to research in topics: Cornea & Visual acuity. The author has an hindex of 105, co-authored 1379 publications receiving 48991 citations. Previous affiliations of Kazuo Tsubota include Chiba University & Showa University.
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Journal ArticleDOI
Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells.
Satoru Yoshida,Miyuki Yasuda,Hideyuki Miyashita,Yoko Ogawa,Tetsu Yoshida,Yumi Matsuzaki,Kazuo Tsubota,Hideyuki Okano,Shigeto Shimmura +8 more
TL;DR: These results suggest that KRT14 and p63 double-positive epithelial progenitor cells can be cloned from iPS cells in order to produce polarized multilayer epithelial cell sheets.
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Transplantation of corneal endothelium with Descemet's membrane using a hyroxyethyl methacrylate polymer as a carrier.
Shigeto Shimmura,Hideyuki Miyashita,Kenji Konomi,Naoshi Shinozaki,Tetsushi Taguchi,Hisatoshi Kobayashi,Jun Shimazaki,Junzo Tanaka,Kazuo Tsubota +8 more
TL;DR: Transplantation of Descemet’s membrane by CCD produces a functional graft with an optically clear interface similar to control cornea, and rabbit control eyes demonstrated stromal oedema caused by loss ofdescemet's membrane, whereas transplanted eyes had clear corneas.
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The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice.
Takeshi Ohguchi,Takashi Kojima,Osama M.A. Ibrahim,Taeko Nagata,Takahiko Shimizu,Takuji Shirasawa,Tetsuya Kawakita,Yoshiyuki Satake,Kazuo Tsubota,Jun Shimazaki,Susumu Ishida +10 more
TL;DR: Application of 2% rebamipide ophthalmic solution for 2 weeks significantly improved the tear film break-up time, the amount of tear production, and the corneal epithelial damage scores, which also significantly increased the conjunctival goblet cell density and muc5 mRNA expression, in the Sod1(-/-) mice.
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Combination Therapy With Diquafosol Tetrasodium and Sodium Hyaluronate in Patients With Dry Eye After Laser In Situ Keratomileusis
TL;DR: The results suggest that hyaluronate and diquafosol combination therapy is beneficial for early stabilization of visual performance and improvement of subjective dry eye symptoms in patients after LASIK.
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Ocular surface treatment before laser in situ keratomileusis in patients with severe dry eye.
TL;DR: LASIK can be safely and effectively managed in patients with severe dry eye with reduced reflex tearing by preoperative and postoperative treatments consisting of a combination of artificial tears, topical autologous serum, and punctal occlusion.