K
Kazuo Tsubota
Researcher at Keio University
Publications - 1421
Citations - 57308
Kazuo Tsubota is an academic researcher from Keio University. The author has contributed to research in topics: Cornea & Visual acuity. The author has an hindex of 105, co-authored 1379 publications receiving 48991 citations. Previous affiliations of Kazuo Tsubota include Chiba University & Showa University.
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Journal ArticleDOI
Low-concentration homogenized castor oil eye drops for noninflamed obstructive meibomian gland dysfunction
Eiki Goto,Jun Shimazaki,Yu Monden,Yoji Takano,Yoji Takano,Yukiko Yagi,Shigeto Shimmura,Shigeto Shimmura,Kazuo Tsubota,Kazuo Tsubota +9 more
TL;DR: The results indicate that castor oil eye drops are effective and safe in the treatment of MGD and the possible mechanisms of this treatment are improvement of tear stability as a result of lipid spreading, ease of meibum expression, prevention of tear evaporation, and the lubricating effect of the oil eye Drops.
Journal Article
Angniotension II Type 1 Receptor–Mediated Inflammation Is Required for Choroidal Neovascularization
Norihiro Nagai,Yuichi Oike,K. Izumi,Takashi Urano,Yoshiaki Kubota,Yoko Ozawa,Makoto Inoue,Kazuo Tsubota,Toshio Suda,Susumu Ishida +9 more
TL;DR: AT1-R–mediated inflammation plays a pivotal role in the development of CNV, indicating the possibility of AT1- R blockade as a novel therapeutic strategy to inhibit CNV.
Journal ArticleDOI
Age-related dysfunction of the lacrimal gland and oxidative stress: Evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice
Takashi Kojima,Tais Hitomi Wakamatsu,Murat Dogru,Murat Dogru,Yoko Ogawa,Ayako Igarashi,Osama M.A. Ibrahim,Takaaki Inaba,Takahiko Shimizu,Setsuko Noda,Hiroto Obata,Shigeru Nakamura,Alda Wakamatsu,Takuji Shirasawa,Jun Shimazaki,Kazuno Negishi,Kazuo Tsubota +16 more
TL;DR: Evidence of epithelial-mesenchymal transition, presence of swollen and degenerated mitochondria, and the presence of apoptotic cell death in the lacrimal glands of senescent Sod1(-/-) mice are revealed.
Journal ArticleDOI
Functional corneal endothelium derived from corneal stroma stem cells of neural crest origin by retinoic acid and Wnt/β-catenin signaling
Shin Hatou,Satoru Yoshida,Kazunari Higa,Hideyuki Miyashita,Emi Inagaki,Hideyuki Okano,Kazuo Tsubota,Shigeto Shimmura +7 more
TL;DR: The induction of functional tissue-engineered corneal endothelium (TECE) from mouse and human COPs is reported, which may lead to a novel stem cell therapy for corNEal endothelial dysfunction.
Journal ArticleDOI
The evaluation of the treatment response in obstructive meibomian gland disease by in vivo laser confocal microscopy.
Yukihiro Matsumoto,Yuta Shigeno,Enrique Adan Sato,Osama M.A. Ibrahim,Megumi Saiki,Kazuno Negishi,Yoko Ogawa,Murat Dogru,Kazuo Tsubota +8 more
TL;DR: In vivo confocal microscopy was able to effectively demonstrate the treatment responses in patients with obstructive meibomian gland disease and inflammatory cell density calculation seems to be a promising new parameter of in vivo conf focal microscopy in the evaluation of treatment responses.