Kazuo Tsubota

TL;DR: In in vivo and in vitro experiments, autologous serum (AS) eye drops showed marked suppression of apoptosis in the conjunctival and corneal epithelium and albumin, the major protein in serum, improved ocular surface damage in vitro and rescued apoptosis after serum deprivation in vitro.

TL;DR: In this article, the authors investigated the clinical and electrophysiologic natural history of Stargardt disease and correlate with the genotype, and found that patients with initial rod ERG involvement demonstrated clinically significant electrophysisiologic deterioration; only 20% of patients with normal full-field ERGs at baseline showed clinically significant progression.

TL;DR: An increase in tear fluid production likely compensates for loss of meibomian glands in individuals with MGD, and this results suggest that non-Sjögren syndrome aqueous-deficient dry eye patients with non-SS ADDE and MGD should be considered at risk of developing MGD.

TL;DR: Transgenic mice made in this study made transgenic mice in which the mouse IL-10 gene was regulated by the human salivary amylase promoter induced apoptosis of glandular tissue destruction and lymphocyte infiltration and Fas/FasL-mediated bystander tissue destruction.

TL;DR: The autologous serum eye drops group showed prolongation of the tear BUT and a reduction in rose bengal staining score and no differences were noted in the subjective scores for dryness between the autOLOGous serumEye drops and artificial tears groups.