Z
Zenjiro Maruyama
Researcher at University of Tokyo
Publications - 7
Citations - 732
Zenjiro Maruyama is an academic researcher from University of Tokyo. The author has contributed to research in topics: Cellular differentiation & Osteoblast. The author has an hindex of 7, co-authored 7 publications receiving 665 citations. Previous affiliations of Zenjiro Maruyama include Osaka University & Nagasaki University.
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Journal ArticleDOI
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
Satoru Kamekura,Yosuke Kawasaki,Kazuto Hoshi,Takashi Shimoaka,Hirotaka Chikuda,Zenjiro Maruyama,Toshihisa Komori,Shingo Sato,Shu Takeda,Gerard Karsenty,Kozo Nakamura,Ung-il Chung,Hiroshi Kawaguchi +12 more
TL;DR: RUNX-2 contributes to the pathogenesis of OA through chondrocyte hypertrophy and matrix breakdown after the induction of joint instability, as compared with wild-type mice.
Journal ArticleDOI
Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency.
Zenjiro Maruyama,Carolina A. Yoshida,Tatsuya Furuichi,Norio Amizuka,Masako Ito,Ryo Fukuyama,Toshihiro Miyazaki,Hideki Kitaura,Kouhei Nakamura,Takashi Fujita,Naoko Kanatani,Takeshi Moriishi,Kei Yamana,Wenguang Liu,Hiroshi Kawaguchi,Kozo Nakamura,Toshihisa Komori +16 more
TL;DR: These findings indicate that the maturity and turnover rate of bone are determined by the level of functional Runx2 and Run x2 is responsible for bone loss in estrogen deficiency, but that Runx 2 is not essential for maintenance of the expression of major bone matrix protein genes in postnatal bone development and maintenance.
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SP7 Inhibits Osteoblast Differentiation at a Late Stage in Mice
Carolina A. Yoshida,Hisato Komori,Zenjiro Maruyama,Zenjiro Maruyama,Toshihiro Miyazaki,Keishi Kawasaki,Keishi Kawasaki,Tatsuya Furuichi,Ryo Fukuyama,Masako Mori,Kei Yamana,Kouhei Nakamura,Wenguang Liu,Satoru Toyosawa,Takeshi Moriishi,Hiroshi Kawaguchi,Kenji Takada,Toshihisa Komori +17 more
TL;DR: It is suggested that SP7 and RUNX2 inhibit osteoblast differentiation at a late stage in a manner independent of RUNx2 and SP7, respectively, andSP7 positively regulates its own promoter.
Journal ArticleDOI
Impairment of bone healing by insulin receptor substrate-1 deficiency.
Takashi Shimoaka,Satoru Kamekura,Hirotaka Chikuda,Kazuto Hoshi,Ung-il Chung,Toru Akune,Zenjiro Maruyama,Toshihisa Komori,Michihiro Matsumoto,Wataru Ogawa,Yasuo Terauchi,Takashi Kadowaki,Kozo Nakamura,Hiroshi Kawaguchi +13 more
TL;DR: It is concluded that IRS-1 deficiency impairs bone healing at least partly by inhibiting chondrocyte proliferation through the phosphatidylinositol 3-kinase/Akt pathway, and it is proposed that taxon receptor substrate-1 can be a target molecule for bone regenerative medicine.
Journal ArticleDOI
Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis
Takeshi Moriishi,Zenjiro Maruyama,Zenjiro Maruyama,Ryo Fukuyama,Masako Ito,Toshihiro Miyazaki,Hideki Kitaura,Hideki Kitaura,Hidetake Ohnishi,Hidetake Ohnishi,Tatsuya Furuichi,Tatsuya Furuichi,Yosuke Kawai,Ritsuko Masuyama,Hisato Komori,Kenji Takada,Hiroshi Kawaguchi,Toshihisa Komori +17 more
TL;DR: Findings indicate that overexpression of BCL2 in osteoblasts inhibits osteoblast differentiation, reduces osteocyte processes, and causes osteocyte apoptosis.