Keiko Akasaka-Manya

TL;DR: It is shown that enzyme activities of three major α-dystroglycanopathy-causing proteins are involved in the synthesis of tandem Rbo5P, a phosphoric ester of pentose alcohol in α-DG.

TL;DR: It is shown that POMT1 forms a complex with PomT2 and the complex possesses protein O-mannosyltransferase activity and the results indicate that the mutant POMt1s could form heterocomplexes with POMTs but that such complexes are insufficient for enzymatic activity.

TL;DR: Results suggest that upregulation of GnT-III in AD brains may represent an adaptive response to protect them from additional beta-amyloid production.

TL;DR: The results indicate that mutations in the POMT1 gene result in a defect of protein O-mannosylation in WWS patients, which may cause failure of binding between alpha-dystroglycan and laminin or other molecules in the extracellular matrix and interrupt normal muscular function and migration of neurons in developing brain.

TL;DR: It is reported that TMEM5 is a xylosyltransferase that forms the Xylβ1-4Rbo5P linkage on O-mannosyl glycan, and acts as a UDP-d-xylose:ribitol-5-phosphate β1,4-xYLosyl transferase in the biosynthetic pathway of O-manic glycan.