K
Keith Burridge
Researcher at University of North Carolina at Chapel Hill
Publications - 36
Citations - 24881
Keith Burridge is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Focal adhesion & Actin cytoskeleton. The author has an hindex of 32, co-authored 36 publications receiving 24219 citations. Previous affiliations of Keith Burridge include Cold Spring Harbor Laboratory & Laboratory of Molecular Biology.
Papers
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Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
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Focal adhesions: Transmembrane junctions between the extracellular matrix and the cytoskeleton
TL;DR: This paper presents a meta-analysis of the phytochemical properties of phosphorous and its applications in the context of Alzheimer’s disease.
Journal ArticleDOI
Focal adhesions, contractility, and signaling
TL;DR: Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture and are regions of signal transduction that relate to growth control.
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Rho and Rac Take Center Stage
TL;DR: This work will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins.
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Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
TL;DR: It is demonstrated that stimulation of fibroblasts with lysophosphatidic acid, which activates rho, induces myosin light chain phosphorylation, which precedes the formation of stress fibers and focal adhesions and is accompanied by increased contractility.