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Keith C. Fernandez
Researcher at Cornell University
Publications - 11
Citations - 1313
Keith C. Fernandez is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 7 publications receiving 859 citations. Previous affiliations of Keith C. Fernandez include Memorial Sloan Kettering Cancer Center & European Bioinformatics Institute.
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Journal ArticleDOI
Extensive impact of non-antibiotic drugs on human gut bacteria
Lisa A. Maier,Mihaela Pruteanu,Michael Kuhn,Georg Zeller,Anja Telzerow,Exene Erin Anderson,Ana Rita Brochado,Keith C. Fernandez,Hitomi Dose,Hirotada Mori,Kiran Raosaheb Patil,Peer Bork,Athanasios Typas +12 more
TL;DR: For example, this paper screened more than 1,000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited the growth of at least one strain in vitro.
Journal ArticleDOI
Dendritic cell–derived hepcidin sequesters iron from the microbiota to promote mucosal healing
Nicholas J. Bessman,Jacques Mathieu,Cyril Renassia,Lei Zhou,Thomas C. Fung,Keith C. Fernandez,Christine Austin,Jesper B. Moeller,Sara Zumerle,Sabine Louis,Sophie Vaulont,Nadim J. Ajami,Harry Sokol,Gregory G. Putzel,Tara Arvedson,Robbyn Sockolow,Samira Lakhal-Littleton,Suzanne M. Cloonan,Suzanne M. Cloonan,Manish Arora,Carole Peyssonnaux,Gregory F. Sonnenberg +21 more
TL;DR: Conventional dendritic cells (cDCs) are identified as a source of hepcidin that is induced by microbial stimulation in mice, prominent in the inflamed intestine of humans, and essential for tissue repair.
Journal ArticleDOI
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
Philipp Walch,Joel Selkrig,Leigh A. Knodler,Mandy Rettel,Frank Stein,Keith C. Fernandez,Cristina Viéitez,Clement M. Potel,Karoline Scholzen,Matthias Geyer,Klemens Rottner,Olivia Steele-Mortimer,Mikhail M. Savitski,David W. Holden,Athanasios Typas +14 more
TL;DR: In this paper, a library of 32 Salmonella enterica serovar Typhimurium (STm) strains expressing chromosomally encoded affinity-tagged effectors and quantified effector-host PPIs in macrophages and epithelial cells.
Posted ContentDOI
Global mapping of Salmonella enterica-host protein-protein interactions during infection
Philipp Walch,Joel Selkrig,Leigh A. Knodler,Leigh A. Knodler,Mandy Rettel,Frank Stein,Keith C. Fernandez,Keith C. Fernandez,Cristina Viéitez,Clement M. Potel,Karoline Scholzen,Matthias Geyer,Klemens Rottner,Olivia Steele-Mortimer,Mikhail M. Savitski,David W. Holden,Athanasios Typas +16 more
TL;DR: To systematically map effector-host protein-protein interactions (PPIs) during infection, a library of 32 Salmonella enterica serovar Typhimurium strains expressing chromosomally encoded affinity-tagged effector proteins was generated, and PPIs in macrophages and epithelial cells were quantified by Affinity-Purification Quantitative Mass-Spectrometry.
Journal ArticleDOI
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization
William T. Yewdell,Young Jun Kim,Priyanka Chowdhury,Colleen M. Lau,Ryan M. Smolkin,Kalina T. Belcheva,Keith C. Fernandez,Montserrat Cols,Wei-Feng Yen,Bharat Vaidyanathan,Davide Angeletti,Adrian B. McDermott,Jonathan W. Yewdell,Joseph C. Sun,Jayanta Chaudhuri,Jayanta Chaudhuri,Jayanta Chaudhuri +16 more
TL;DR: Findings indicate a crucial role for G4 binding in AID targeting and suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to the physiology and pathology of activated B cells.