Kelly J. Pittman

TL;DR: RNA-seq is a valuable tool to simultaneously analyze host and microbe transcriptomes and shows that T. gondii is metabolically active and synthesizing proteins at 28 days post-infection and that a distinct subset of host genes associated with the immune response are more abundant specifically during chronic infection.

TL;DR: An overview of what is known and unknown about the complex relationship between the host and parasite during the progression of T. gondii infection is provided, with the ultimate goal of bridging these events.

TL;DR: RNA-seq of cells infected with either ΔsarA or wild-type S. Typhimurium revealed that SarA activates STAT3 transcriptional targets and contributes to intracellular replication in vitro and bacterial load at systemic sites in mice, demonstrating that Salmonella has evolved mechanisms for activating an important anti-inflammatory pathway.

TL;DR: The Hi-HOST Phenome Project (H2P2) is reported, a catalog of cellular genome-wide association studies (GWAS) comprising 79 infection-related phenotypes in response to 8 pathogens in 528 lymphoblastoid cell lines and a SNP in the transcriptional repressor ZBTB20 demonstrated pleiotropy, likely through suppression of multiple target genes, and was associated with viral hepatitis.

TL;DR: Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients.