S
Scott Jag.
Researcher at University of London
Publications - 12
Citations - 321
Scott Jag. is an academic researcher from University of London. The author has contributed to research in topics: Pneumonia & Population. The author has an hindex of 7, co-authored 12 publications receiving 244 citations. Previous affiliations of Scott Jag. include Wellcome Trust & Kenya Medical Research Institute.
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Journal ArticleDOI
Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study
Daniel R. Feikin,Wei Fu,Daniel E. Park,Daniel E. Park,Qiyuan Shi,Melissa M. Higdon,Henry C. Baggett,Brooks Wa,Deloria Knoll M,Laura L. Hammitt,Laura L. Hammitt,Howie Src,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,Shabir A. Madhi,Scott Jag.,Donald M. Thea,Peter V. Adrian,Peter V. Adrian,Martin Antonio,Martin Antonio,Martin Antonio,Juliet O. Awori,Vicky L. Baillie,Vicky L. Baillie,Andrea DeLuca,Amanda J. Driscoll,Bernard E. Ebruke,Doli Goswami,Ruth A. Karron,Mengying Li,Susan C. Morpeth,Susan C. Morpeth,Susan C. Morpeth,John Mwaba,James Mwansa,Christine Prosperi,Pongpun Sawatwong,Samba O. Sow,Tapia,Toni Whistler,K. Zaman,Scott L. Zeger,O' Brien Kl,David R. Murdoch +45 more
TL;DR: Although higher viral loads among pneumonia cases than controls for some viruses are found, the utility in using viral load of URT specimens to define viral pneumonia was equivocal and analysis was limited by lack of a gold standard for viral pneumonia.
Journal ArticleDOI
The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia
Amanda J. Driscoll,Deloria Knoll M,Laura L. Hammitt,Laura L. Hammitt,Henry C. Baggett,Brooks Wa,Daniel R. Feikin,Daniel R. Feikin,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,Shabir A. Madhi,Katherine L O'Brien,Scott Jag.,Donald M. Thea,Howie Src,Peter V. Adrian,Peter V. Adrian,Dilruba Ahmed,Andrea DeLuca,Bernard E. Ebruke,Caroline W. Gitahi,Melissa M. Higdon,Anek Kaewpan,Angela Karani,Ruth A. Karron,Razib Mazumder,Jessica McLellan,Jessica McLellan,David P. Moore,David P. Moore,Lawrence Mwananyanda,Lawrence Mwananyanda,Daniel E. Park,Daniel E. Park,Christine Prosperi,Julia Rhodes,Muhammad Saifullah,Phil Seidenberg,Phil Seidenberg,Samba O. Sow,Boubou Tamboura,Scott L. Zeger,David R. Murdoch +43 more
TL;DR: Antibiotic exposure and blood culture volume affect detection of bacterial pathogens in children with pneumonia and should be accounted for in studies of etiology and in clinical management.
Journal ArticleDOI
Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis
Liuyang Wang,Emily R Ko,Emily R Ko,James J. Gilchrist,James J. Gilchrist,Kelly J. Pittman,Anna Rautanen,Matti Pirinen,J. W. Thompson,Laura G. Dubois,Raymond J. Langley,Sarah L. Jaslow,Raul E. Salinas,Douglas C. Rouse,M.A. Moseley,Salim Mwarumba,Patricia Njuguna,Neema Mturi,Thomas N. Williams,Thomas N. Williams,Scott Jag.,Hill Avs.,Hill Avs.,Christopher W. Woods,Christopher W. Woods,Christopher W. Woods,Geoffrey S. Ginsburg,Ephraim L. Tsalik,Ephraim L. Tsalik,Ephraim L. Tsalik,Dennis C. Ko +30 more
TL;DR: Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients.
Journal ArticleDOI
Colonization Density of the Upper Respiratory Tract as a Predictor of Pneumonia-Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii.
Daniel E. Park,Henry C. Baggett,Howie Src,Qiyuan Shi,Nora L. Watson,Brooks Wa,Deloria Knoll M,Laura L. Hammitt,Laura L. Hammitt,Karen L. Kotloff,Orin S. Levine,Orin S. Levine,Shabir A. Madhi,David R. Murdoch,Katherine L. O'Brien,Scott Jag.,Donald M. Thea,Dilruba Ahmed,Martin Antonio,Martin Antonio,Martin Antonio,Vicky L. Baillie,Vicky L. Baillie,Andrea DeLuca,Amanda J. Driscoll,Wei Fu,Caroline W. Gitahi,Emmanuel Olutunde,Melissa M. Higdon,Lokman Hossain,Ruth A. Karron,Abdoul Aziz Maiga,Susan A. Maloney,David P. Moore,David P. Moore,Susan C. Morpeth,Susan C. Morpeth,Susan C. Morpeth,John Mwaba,Musaku Mwenechanya,Christine Prosperi,Mariam Sylla,Somsak Thamthitiwat,Scott L. Zeger,Daniel R. Feikin,Daniel R. Feikin +45 more
TL;DR: There is evidence for an association between H. influenzae–confirmed pneumonia in children; the association may be particularly informative in epidemiologic studies and unlikely to be of diagnostic value in clinical settings.
Journal ArticleDOI
Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.
James J. Gilchrist,James J. Gilchrist,Anna Rautanen,Benjamin P. Fairfax,Tara C. Mills,Vivek Naranbhai,H Trochet,Matti Pirinen,Matti Pirinen,Esther Muthumbi,Salim Mwarumba,Patricia Njuguna,Neema Mturi,Chisomo L. Msefula,Esther N. Gondwe,Jenny M. MacLennan,Jenny M. MacLennan,Stephen J Chapman,Stephen J Chapman,Malcolm E. Molyneux,Julian C. Knight,Spencer Cca.,Thomas N. Williams,Thomas N. Williams,Calman A. MacLennan,Calman A. MacLennan,Scott Jag.,Scott Jag.,Hill Avs.,Hill Avs. +29 more
TL;DR: A genome-wide association study is conducted and genetic variation in STAT4 is shown to be a determinant of NTS in Kenyan and Malawian children, implicate interleukin-12-dependent IFNγ-mediated immunity as a determinants of invasive NTS disease in African children.