K
Kendall N. Houk
Researcher at University of California, Los Angeles
Publications - 1025
Citations - 62686
Kendall N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 112, co-authored 997 publications receiving 54877 citations. Previous affiliations of Kendall N. Houk include Texas A&M University & University of Notre Dame.
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Journal ArticleDOI
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger,Olga Khersonsky,Andrew M. Wollacott,Lin Jiang,Jason DeChancie,Jamie L. Betker,Jasmine L. Gallaher,Eric A. Althoff,Alexandre Zanghellini,Orly Dym,Shira Albeck,Kendall N. Houk,Dan S. Tawfik,David Baker +13 more
TL;DR: The computational design of eight enzymes that use two different catalytic motifs to catalyse the Kemp elimination—a model reaction for proton transfer from carbon—with measured rate enhancements of up to 105 and multiple turnovers are described.
Journal ArticleDOI
De novo computational design of retro-aldol enzymes.
Lin Jiang,Eric A. Althoff,Fernando R. Clemente,Lindsey Doyle,Daniela Röthlisberger,Alexandre Zanghellini,Jasmine L. Gallaher,Jamie L. Betker,Fujie Tanaka,Carlos F. Barbas,Donald Hilvert,Kendall N. Houk,Barry L. Stoddard,David Baker +13 more
TL;DR: Using new algorithms that rely on hashing techniques to construct active sites for multistep reactions, retro-aldolases that use four different catalytic motifs to catalyze the breaking of a carbon-carbon bond in a nonnatural substrate are designed.
Journal ArticleDOI
Benchmarking the Conductor-like Polarizable Continuum Model (CPCM) for Aqueous Solvation Free Energies of Neutral and Ionic Organic Molecules.
Yu Takano,Kendall N. Houk +1 more
TL;DR: The conductor-like polarizable continuum model (CPCM) using several cavity models is applied to compute aqueous solvation free energies for a number of organic molecules (30 neutral molecules, 21 anions, and 19 cations) to compare to the available experimental data.
Journal ArticleDOI
Analyzing Reaction Rates with the Distortion/Interaction‐Activation Strain Model
TL;DR: This model has been applied to reactions of all types in both organic and inorganic chemistry, including substitutions and eliminations, cycloadditions, and several types of organometallic reactions.
Journal ArticleDOI
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction
Justin B. Siegel,Alexandre Zanghellini,Helena M. Lovick,Gert Kiss,Abigail R. Lambert,Jennifer L. St.Clair,Jasmine L. Gallaher,Donald Hilvert,Michael H. Gelb,Barry L. Stoddard,Kendall N. Houk,Forrest E. Michael,David Baker +12 more
TL;DR: The design of enzymes that catalyze the bimolecular Diels-Alder reaction, a carbon-carbon bond formation reaction that is central to organic synthesis but unknown in natural metabolism, is described.