K
Kendall N. Houk
Researcher at University of California, Los Angeles
Publications - 1025
Citations - 62686
Kendall N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 112, co-authored 997 publications receiving 54877 citations. Previous affiliations of Kendall N. Houk include Texas A&M University & University of Notre Dame.
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Extraordinary Difference in Reactivity of Ozone (OOO) and Sulfur Dioxide (OSO): A Theoretical Study.
TL;DR: Valence bond calculations also show that while ozone has a high degree of diradical character, SO2 does not, and is better characterized as a dritterion.
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A theoretical investigation of phosphonamidates and sulfonamides as protease transition state isosteres
TL;DR: In this paper, the conformations and electrostatic potentials of phosphonamides, phosphonamide candidates and sulfonamide are compared to the tetrahedral intermediate for base-catalyzed amide hydrolysis.
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Reactivity of (eta(6)-arene)tricarbonylchromium complexes toward additions of anions, cations, and radicals.
TL;DR: Density functional theory calculations using the B3LYP method showed that tricarbonylchromium stabilizes all three types of intermediates, and computational results for anionic addition agree well with established chemistry and provide structural and energetic details as reference points for comparison with the other reactive intermediates.
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Engineering synthetic recursive pathways to generate non-natural small molecules
TL;DR: An artificial pathway for αKA elongation has been built that uses an engineered isopropylmalate synthase to recursively condense acetyl-CoA with αKAs, which serves as a case study for understanding the challenges of building recursive pathways from nonrecursive enzymes.
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How Cinchona Alkaloid-Derived Primary Amines Control Asymmetric Electrophilic Fluorination of Cyclic Ketones
Yu-hong Lam,Kendall N. Houk +1 more
TL;DR: The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines and the chair preference of a seven-membered ring at the fluorine transfer transition state are determined with density functional calculations.