K
Kendall N. Houk
Researcher at University of California, Los Angeles
Publications - 1025
Citations - 62686
Kendall N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 112, co-authored 997 publications receiving 54877 citations. Previous affiliations of Kendall N. Houk include Texas A&M University & University of Notre Dame.
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Journal ArticleDOI
Electronic and Steric Control of Regioselectivities in Rh(I)‐Catalyzed [5 + 2] Cycloadditions: Experiment and Theory.
Peng Liu,Lauren E. Sirois,Paul Ha-Yeon Cheong,Zhi-Xiang Yu,Ingo V. Hartung,Heiko Rieck,Paul A. Wender,Kendall N. Houk +7 more
TL;DR: Bulky and electron-rich alkyne substituents are leading to preferential formation of (2,5)-alkyne as discussed by the authors. But the preferential formation is not always optimal.
Journal ArticleDOI
Acyclic Stereocontrol in the Additions of Nucleophilic Alkenes to α‐Chiral N‐Sulfonyl Imines
Lucas C. Moore,Anna Lo,Jason S. Fell,Matthew R. Duong,Jose A Moreno,Barry E Rich,Martin Bravo,James C. Fettinger,Lucas W. Souza,Marilyn M. Olmstead,Kendall N. Houk,Jared T. Shaw +11 more
TL;DR: Development of conditions to produce both syn and anti products with high diastereoselectivity and good yields is described, and a stereoelectronic model consistent with experimental outcomes is proposed.
Mechanism of Permanganate-Promoted Dihydroxylation of Complex Diketopiperazines: Critical Roles of Counter-cation and Ion-Pairing
Brandon E. Haines,Brandon M. Nelson,Jessica M. Grandner,Justin Kim,Kendall N. Houk,Mohammad Movassaghi,Djamaladdin G. Musaev +6 more
TL;DR: The developed mechanistic knowledge was used to rationalize an experimentally observed oxidation pattern for C3-indole-substituted diketopiperazine (+)-5 under optimal oxidation conditions: namely, the formation of diol (-)-6 as a single diastereomer and lack of the ketone products.
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Origins and predictions of stereoselectivity in intramolecular aldol reactions catalyzed by proline derivatives
TL;DR: Computational investigations of the Hajos-Parrish-Eder-Sauer-Wiechert reaction catalyzed by various proline derivatives reveal the origins of stereoselectivity and led to predictions for new catalysts as discussed by the authors.