K
Kendall N. Houk
Researcher at University of California, Los Angeles
Publications - 1025
Citations - 62686
Kendall N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 112, co-authored 997 publications receiving 54877 citations. Previous affiliations of Kendall N. Houk include Texas A&M University & University of Notre Dame.
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Distortion-Controlled Reactivity and Molecular Dynamics of Dehydro-Diels–Alder Reactions
TL;DR: D density functional theory studies of a series of dehydro-Diels-Alder reactions reveal that productive concerted trajectories display a strong angle bending oscillation, while the stepwise trajectories show only a chaotic pattern and less pronounced bending vibrations.
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Diels-Alder reactions between trans-1-N-acylamino-1,3-dienes and methyl acrylate. A correlation between diene photoelectron ionization potentials and reactivity, stereoselectivity, and regioselectivity
TL;DR: In this article, a quantitative study of the Diels-Alder reaction of a series of trans-N-acylamino-l, 3-butadienes (1) and methyl acrylate is reported.
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Influence of water and enzyme SpnF on the dynamics and energetics of the ambimodal [6+4]/[4+2] cycloaddition.
Zhongyue Yang,Song Yang,Peiyuan Yu,Yanwei Li,Yanwei Li,Charles Doubleday,Jiyong Park,Ashay Patel,Ashay Patel,Byung Sun Jeon,William K. Russell,Hung-wen Liu,David H. Russell,Kendall N. Houk +13 more
TL;DR: An efficient method, environment-perturbed transition-state sampling, is developed to study single-molecule trajectories in enzymes and calculate activation barriers, and will find great application in the design of enzymes to control selectivity, particularly for reactions involving ambimodal transition states.
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The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms.
TL;DR: The mechanism involves the formation of a carboxylate mixed formimidic anhydride intermediate via a concerted mechanism which is then transformed to an N-formylamide by a concerted pseudopericyclic [1,3]-acyl shift.