K
Kendall N. Houk
Researcher at University of California, Los Angeles
Publications - 1025
Citations - 62686
Kendall N. Houk is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Catalysis & Cycloaddition. The author has an hindex of 112, co-authored 997 publications receiving 54877 citations. Previous affiliations of Kendall N. Houk include Texas A&M University & University of Notre Dame.
Papers
More filters
Journal ArticleDOI
Rapid Catalyst Identification for the Synthesis of the Pyrimidinone Core of HIV Integrase Inhibitors
Ana Bellomo,Nihan Çelebi-Ölçüm,Xiaodong Bu,Nelo R. Rivera,Rebecca T. Ruck,Christopher J. Welch,Kendall N. Houk,Spencer D. Dreher +7 more
TL;DR: A microscale chemistry improvement engine: a pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement, resulting in two high-quality catalytic systems for the construction of the title compound 1.
Journal ArticleDOI
Rational design and atroposelective synthesis of N–N axially chiral compounds
Guang-Jian Mei,Guang-Jian Mei,Jonathan J. Wong,Wenrui Zheng,Anjanay A. Nangia,Kendall N. Houk,Yixin Lu +6 more
TL;DR: The first catalytic asymmetric synthesis of N–N axially chiral compounds has been accomplished via a quinidine catalyzed N-allylic alkylation reaction via DFT calculations to understand the origin of enantioselectivity and provide guidance for the design of additional molecules of this type.
Journal ArticleDOI
Role of Orbital Interactions and Activation Strain (Distortion Energies) on Reactivities in the Normal and Inverse Electron-Demand Cycloadditions of Strained and Unstrained Cycloalkenes.
Brian J. Levandowski,Trevor A. Hamlin,F. Matthias Bickelhaupt,F. Matthias Bickelhaupt,Kendall N. Houk +4 more
TL;DR: The Diels-Alder reactivities of a series of cycloalkenes, from the highly strained cyclopropene to the unstrained cyclohexene, have been studied with density functional theory and it is revealed that the reactivity trends result from differences in the strength of the primary and secondary orbital interactions.
Journal ArticleDOI
QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis.
TL;DR: These results do not support the direct decarboxylation mechanism that has been proposed for the enzyme, however, in the context of QM/MM calculations, it was found that the size of the QM region has a dramatic effect on the calculated reaction barrier.
Journal ArticleDOI
On the Mechanism of Ligand-Assisted, Copper-Catalyzed Benzylic Amination by Chloramine-T
TL;DR: The mechanism of hydrocarbon amination by chloramine-T derivatives catalyzed by (diimine)copper complexes has been investigated in this paper, and the initial synthetic study revealed ligand-acceler...