K
Kenneth E. Viar
Researcher at University of Virginia
Publications - 17
Citations - 1918
Kenneth E. Viar is an academic researcher from University of Virginia. The author has contributed to research in topics: Neuron & Rostral ventrolateral medulla. The author has an hindex of 15, co-authored 17 publications receiving 1228 citations. Previous affiliations of Kenneth E. Viar include University of Virginia Health System.
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Journal ArticleDOI
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Sandro Da Mesquita,Antoine Louveau,Andrea Vaccari,Igor Smirnov,R. Chase Cornelison,Kathryn M. Kingsmore,Christian Contarino,Christian Contarino,Suna Onengut-Gumuscu,Emily Farber,Daniel M.S. Raper,Daniel M.S. Raper,Kenneth E. Viar,Romie D. Powell,Wendy Baker,Nisha Dabhi,Robin Bai,Rui Cao,Song Hu,Stephen S. Rich,Jennifer M. Munson,Jennifer M. Munson,M. Beatriz S. Lopes,Christopher C. Overall,Scott T. Acton,Jonathan Kipnis +25 more
TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.
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CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Antoine Louveau,Jasmin Herz,Maria Nordheim Alme,Andrea Francesca Salvador,Michael Q. Dong,Kenneth E. Viar,S. Grace Herod,James Knopp,Joshua C. Setliff,Alexander L. Lupi,Sandro Da Mesquita,Elizabeth L. Frost,Alban Gaultier,Tajie H. Harris,Rui Cao,Song Hu,John R. Lukens,Igor Smirnov,Christopher C. Overall,Guillermo Oliver,Jonathan Kipnis +20 more
TL;DR: It is demonstrated that meningeal lymphatics drain CSF-derived macromolecules and immune cells and play a key role in regulating neuroinflammation and may represent a new therapeutic target for multiple sclerosis.
Journal ArticleDOI
C1 neurons mediate a stress-induced anti-inflammatory reflex in mice
Chikara Abe,Tsuyoshi Inoue,Mabel A Inglis,Kenneth E. Viar,Liping Huang,Hong Ye,Diane L. Rosin,Ruth L. Stornetta,Mark D. Okusa,Patrice G. Guyenet +9 more
TL;DR: Overall, acute stress attenuated IRI by activating a cholinergic, predominantly sympathetic, anti-inflammatory pathway, and C1s were necessary and sufficient to mediate this effect.
Journal ArticleDOI
Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State–Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats
Peter G R Burke,Stephen B. G. Abbott,Melissa B. Coates,Kenneth E. Viar,Ruth L. Stornetta,Patrice G. Guyenet +5 more
TL;DR: C1 cell stimulation reproduces most effects of acute hypoxia, specifically cardiorespiratory stimulation, sighs, and arousal and likely contributes to the sleep disruption and adverse autonomic consequences of sleep apnea.
Journal ArticleDOI
State‐dependent control of breathing by the retrotrapezoid nucleus
Peter G R Burke,Roy Kanbar,Tyler M. Basting,Walter M. Hodges,Kenneth E. Viar,Ruth L. Stornetta,Patrice G. Guyenet +6 more
TL;DR: The HCVR is reduced during REM sleep because fR is no longer under chemoreceptor control and thus could explain why central sleep apnoea is less frequent in REM sleep.