R
R. Chase Cornelison
Researcher at Virginia Tech
Publications - 14
Citations - 953
R. Chase Cornelison is an academic researcher from Virginia Tech. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 7, co-authored 12 publications receiving 563 citations. Previous affiliations of R. Chase Cornelison include University of Massachusetts Amherst & University of Texas at Austin.
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Journal ArticleDOI
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Sandro Da Mesquita,Antoine Louveau,Andrea Vaccari,Igor Smirnov,R. Chase Cornelison,Kathryn M. Kingsmore,Christian Contarino,Christian Contarino,Suna Onengut-Gumuscu,Emily Farber,Daniel M.S. Raper,Daniel M.S. Raper,Kenneth E. Viar,Romie D. Powell,Wendy Baker,Nisha Dabhi,Robin Bai,Rui Cao,Song Hu,Stephen S. Rich,Jennifer M. Munson,Jennifer M. Munson,M. Beatriz S. Lopes,Christopher C. Overall,Scott T. Acton,Jonathan Kipnis +25 more
TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.
Journal ArticleDOI
Electroactive tissue scaffolds with aligned pores as instructive platforms for biomimetic tissue engineering
John G. Hardy,R. Chase Cornelison,Rushi C. Sukhavasi,Richard J. Saballos,Philip Vu,David L. Kaplan,Christine E. Schmidt +6 more
TL;DR: It is reported that the dissolution of the sacrificial urea yields scaffolds with macroscopic pores that are aligned over long, clinically-relevant distances (i.e., centimeter scale) and the pores act as topographical cues to which rat Schwann cells respond by aligning with the long axis of the pores.
Journal ArticleDOI
Injectable hydrogels of optimized acellular nerve for injection in the injured spinal cord.
R. Chase Cornelison,R. Chase Cornelison,Elisa J. Gonzalez-Rothi,Stacy Porvasnik,Steven M. Wellman,James H. Park,David D. Fuller,Christine E. Schmidt +7 more
TL;DR: The data indicate that this novel injectable form of acellular nerve grafts is amenable for use after contusion SCI and may bolster a simultaneous therapy by acutely modulating the inflammatory milieu and supporting axonal growth.
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Instructive Conductive 3D Silk Foam‐Based Bone Tissue Scaffolds Enable Electrical Stimulation of Stem Cells for Enhanced Osteogenic Differentiation
John G. Hardy,Sydney A. Geissler,Sydney A. Geissler,David Aguilar,Maria K. Villancio-Wolter,David J. Mouser,Rushi C. Sukhavasi,R. Chase Cornelison,R. Chase Cornelison,Lee W. Tien,R. Carmen Preda,Rebecca S. Hayden,Jacqueline K. Chow,Lindsey Nguy,David L. Kaplan,Christine E. Schmidt +15 more
TL;DR: The preparation of conductive silk foam-based bone tissue scaffolds that enable the electrical stimulation of human mesenchymal stem cells to enhance their differentiation toward osteogenic outcomes are described.
Journal ArticleDOI
Convective forces increase CXCR4-dependent glioblastoma cell invasion in GL261 murine model
R. Chase Cornelison,R. Chase Cornelison,Caroline E. Brennan,Kathryn M. Kingsmore,Jennifer M. Munson,Jennifer M. Munson +5 more
TL;DR: It is shown that expression of CXCR4 and CXCL12 is increased in patients having received standard therapy, when CED might be elected, and targeting flow-stimulated invasion may prove beneficial as a second line of therapy, particularly in patients chosen to receive treatment by convection enhanced delivery.