Rui Cao

TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.

TL;DR: It is demonstrated that meningeal lymphatics drain CSF-derived macromolecules and immune cells and play a key role in regulating neuroinflammation and may represent a new therapeutic target for multiple sclerosis.

TL;DR: First‐of‐a‐kind head‐restrained photoacoustic microscopy (PAM), which enables simultaneous imaging of the cerebrovascular anatomy, total concentration and oxygen saturation of hemoglobin, and blood flow in awake mice, opens a new avenue for basic and translational research on neurovascular coupling without the strong influence of anesthesia.

TL;DR: A multi-parametric PAM platform is developed and for the first time-simultaneous wide-field PAM of all three parameters down to the capillary level in vivo is demonstrated.

TL;DR: Capable of imaging all three hemodynamic parameters at the same spatiotemporal scale, the newly developed ultrasound-aided multi-parametric photoacoustic microscopy (PAM) fills a critical gap in preclinical neuroimaging and lays the foundation for high-resolution mapping of the cerebral metabolic rate of oxygen (CMRO2)—a quantitative index of cerebral oxygen metabolism.