Kathryn M. Kingsmore

TL;DR: It is shown that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice and improves brain perfusion and learning and memory performance.

TL;DR: In this paper, the authors carried out a comprehensive analysis of gene expression data from the blood, lung, and airway of COVID-19 patients, and found that the myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment contribute to disease pathogenesis.

TL;DR: Results indicate that COVID-19 pathogenesis is driven by populations of myeloid-lineage cells with highly inflammatory but distinct transcriptional signatures in each compartment, and suggests that transcriptomic profiling can provide an understanding of the pathogenesis of CO VID-19 in individual patients.

TL;DR: It is concluded that FUS-mediated BTB/BBB opening yields markedly augmented interstitial tumor flow that, in turn, plays a critical role in enhancing BPN transport through tumor tissue.

TL;DR: Examination of IFF-stimulated CXCR4-, CXCL12-, and CD44-dependent invasion in patient-derived glioblastoma stem cells (GSCs) indicates that different mechanisms govern the flow response across GSCs, but that within a single patient, there are subpopulations of G SCs that respond to flow via eitherCD44- or CX CR4-CXCL 12 mechanisms.