Franklin L. Zhong

TL;DR: ChIRP-seq of three lncRNAs reveal that RNA occupancy sites in the genome are focal, sequence-specific, and numerous, and generally applicable to illuminate the intersection of RNA and chromatin with newfound precision genome wide.

TL;DR: Micromanipulation methods show that nuclei in human embryonic stem cells are highly deformable and stiffen 6-fold through terminal differentiation, and that nucleo-skeletal components in human adult stem cells possess an intermediate stiffness and deform irreversibly.

TL;DR: Congruence in outcome between responses to IFN-β in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS) is found and a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFn-β.

TL;DR: It is found that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC) and the first genetic evidence linkingNLRP1 to skin inflammatory syndromes and skin cancer predisposition is provided.

TL;DR: It is shown that the OB-fold domain of the telomere-binding protein TPP1 recruits telomersase to telomeres through an association with the telomerase reverse transcriptase TERT, and this data defines a potential interface for telomerases-TPP1 interaction required forTelomere maintenance and implicate defective telomer enzyme recruitment in telomerasing-related disease.