K
Kenneth Ryder
Researcher at Guy's Hospital
Publications - 8
Citations - 1049
Kenneth Ryder is an academic researcher from Guy's Hospital. The author has contributed to research in topics: Breast cancer & Metastasis. The author has an hindex of 7, co-authored 8 publications receiving 1010 citations.
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Journal ArticleDOI
Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen.
Sherene Loi,Benjamin Haibe-Kains,Christine Desmedt,Pratyaksha Wirapati,Françoise Lallemand,Andrew Tutt,Cheryl Gillet,Paul Ellis,Kenneth Ryder,James F. Reid,Maria Grazia Daidone,M. A. Pierotti,Els M.J.J. Berns,Maurice P.H.M. Jansen,John A. Foekens,Mauro Delorenzi,Gianluca Bontempi,Martine Piccart,Christos Sotiriou +18 more
TL;DR: A gene classifier that can predict clinical outcome in tamoxifen-treated ER+ BC patients is developed and other genes and pathways that may elucidate further mechanisms that influence clinical outcome and prediction of response to tamoxIFen are proposed.
Journal ArticleDOI
Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
L G Fulford,L G Fulford,Jorge S. Reis-Filho,Kenneth Ryder,Chris Jones,Cheryl Gillett,Andrew M. Hanby,Douglas F. Easton,Sunil R. Lakhani,Sunil R. Lakhani +9 more
TL;DR: Compared to other grade III tumours, basal-like tumours appear to have a relatively good long-term survival but survival after metastases is poor.
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CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness
Patrick Michl,Antoine R. Ramjaun,Olivier E. Pardo,Patricia H. Warne,Martin Wagner,Richard Poulsom,Corrado D'Arrigo,Kenneth Ryder,Andre Menke,Thomas M. Gress,Julian Downward +10 more
TL;DR: CUTL1 activity is associated with increased migration and invasiveness in numerous tumor cell lines, both in vitro and in vivo and it is identified as a transcriptional target of transforming growth factor beta and a mediator of its promigratory effects.
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The pattern of expression of the microtubule‐binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells
TL;DR: It is suggested that RHAMM/IHABP expression may contribute to the motility and invasiveness of a tumour cell sub‐population in breast cancers.
Journal ArticleDOI
Risk estimation of distant metastasis in node-negative, estrogen receptor-positive breast cancer patients using an RT-PCR based prognostic expression signature.
Andrew Tutt,Andrew Tutt,Alice Wang,Charles M. Rowland,C. Gillett,Kit Lau,Karen Chew,Hongyue Dai,Shirley Kwok,Kenneth Ryder,Henry Shu,Robert Springall,Paul Cane,Blair McCallie,Lauren Kam-Morgan,Steve Anderson,Horst Buerger,Joe W. Gray,James L. Bennington,Laura J. Esserman,Trevor Hastie,Samuel Broder,John J. Sninsky,Burkhard Brandt,Fred Waldman,Fred Waldman +25 more
TL;DR: The 14-gene signature found to be significantly associated with risk of distant metastasis has a predominance of proliferation genes which have prognostic significance above that of Ki-67 LI and may aid in prioritizing future mechanistic studies and therapeutic interventions.