K
Kenta Takahashi
Researcher at National Institutes of Health
Publications - 32
Citations - 2209
Kenta Takahashi is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Virus & Progressive multifocal leukoencephalopathy. The author has an hindex of 12, co-authored 27 publications receiving 1300 citations.
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Journal ArticleDOI
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development.
Masaki Imai,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Samantha Loeber,Peter Halfmann,Noriko Nakajima,Tokiko Watanabe,Michiko Ujie,Kenta Takahashi,Mutsumi Ito,Shinya Yamada,Shufang Fan,Shiho Chiba,Makoto Kuroda,Lizheng Guan,Kosuke Takada,Tammy Armbrust,Aaron Balogh,Yuri Furusawa,Moe Okuda,Hiroshi Ueki,Atsuhiro Yasuhara,Yuko Sakai-Tagawa,Tiago J. S. Lopes,Tiago J. S. Lopes,Maki Kiso,Seiya Yamayoshi,Noriko Kinoshita,Norio Ohmagari,Shin-ichiro Hattori,Makoto Takeda,Hiroaki Mitsuya,Florian Krammer,Tadaki Suzuki,Yoshihiro Kawaoka,Yoshihiro Kawaoka +35 more
TL;DR: It is found that SARS-CoV-2 isolates replicate efficiently in the lungs of Syrian hamsters and cause severe pathological lesions in the lung of these animals similar to commonly reported imaging features of COVID-19 patients with pneumonia.
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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
Yixuan J. Hou,Shiho Chiba,Peter Halfmann,Camille Ehre,Makoto Kuroda,Kenneth H. Dinnon,Sarah R. Leist,Alexandra Schäfer,Noriko Nakajima,Kenta Takahashi,Rhianna E. Lee,Teresa M. Mascenik,Rachel L. Graham,Caitlin E. Edwards,Longping V. Tse,Kenichi Okuda,Alena J. Markmann,Luther A. Bartelt,Aravinda M. de Silva,David M. Margolis,Richard C. Boucher,Scott H. Randell,Tadaki Suzuki,Lisa E. Gralinski,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Ralph S. Baric +26 more
TL;DR: The current dominant structural variant of SARS-CoV-2 appears to have evolved from the ancestral form and enhances transmissibility, and the mutation renders the new virus variant more susceptible to neutralizing antisera without altering the efficacy of vaccine candidates currently under development.
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A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets
Masaki Imai,Tokiko Watanabe,Maki Kiso,Noriko Nakajima,Seiya Yamayoshi,Kiyoko Iwatsuki-Horimoto,Masato Hatta,Shinya Yamada,Mutsumi Ito,Yuko Sakai-Tagawa,Masayuki Shirakura,Emi Takashita,Seiichiro Fujisaki,Ryan McBride,Andrew J. Thompson,Kenta Takahashi,Tadashi Maemura,Hiromichi Mitake,Shiho Chiba,Gongxun Zhong,Shufang Fan,Kohei Oishi,Atsuhiro Yasuhara,Kosuke Takada,Tomomi Nakao,Satoshi Fukuyama,Makoto Yamashita,Tiago J. S. Lopes,Tiago J. S. Lopes,Gabriele Neumann,Takato Odagiri,Shinji Watanabe,Yuelong Shu,James C. Paulson,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +36 more
TL;DR: The results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
Journal ArticleDOI
Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets.
Masaki Imai,Makoto Yamashita,Yuko Sakai-Tagawa,Kiyoko Iwatsuki-Horimoto,Maki Kiso,Jurika Murakami,Atsuhiro Yasuhara,Kosuke Takada,Mutsumi Ito,Noriko Nakajima,Kenta Takahashi,Tiago J. S. Lopes,Tiago J. S. Lopes,Jayeeta Dutta,Zenab Khan,Divya Kriti,Harm van Bakel,Akifumi Tokita,Haruhisa Hagiwara,Naomi Izumida,Haruo Kuroki,Tamon Nishino,Noriyuki Wada,Michiko Koga,Eisuke Adachi,Daisuke Jubishi,Hideki Hasegawa,Yoshihiro Kawaoka,Yoshihiro Kawaoka +28 more
TL;DR: It is reported that resistant viruses isolated from Japanese patients have normal replicative abilities and pathogenicity in animal models and thus might spread in humans.
Journal ArticleDOI
Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential
Tokiko Watanabe,Gongxun Zhong,Colin A. Russell,Noriko Nakajima,Masato Hatta,Anthony Hanson,Ryan McBride,David F. Burke,Kenta Takahashi,Satoshi Fukuyama,Yuriko Tomita,Eileen A. Maher,Shinji Watanabe,Masaki Imai,Gabriele Neumann,Hideki Hasegawa,James C. Paulson,Derek J. Smith,Yoshihiro Kawaoka +18 more
TL;DR: The phylogenetic and geographic analyses revealed the global prevalence of avian influenza virus genes whose proteins differ only a few amino acids from the 1918 pandemic influenza virus, suggesting that 1918-like pandemic viruses may emerge in the future.