K
Kentaro Hosokawa
Researcher at Kyushu University
Publications - 33
Citations - 5470
Kentaro Hosokawa is an academic researcher from Kyushu University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 20, co-authored 33 publications receiving 5116 citations. Previous affiliations of Kentaro Hosokawa include Keio University.
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Journal ArticleDOI
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
Journal ArticleDOI
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito,Atsushi Hirao,Fumio Arai,Sahoko Matsuoka,Keiyo Takubo,Isao Hamaguchi,Kana Nomiyama,Kentaro Hosokawa,Kazuhiro Sakurada,Naomi Nakagata,Yasuo Ikeda,Tak W. Mak,Toshio Suda +12 more
TL;DR: It is shown that ATM has an essential function in the reconstitutive capacity of haematopoietic stem cells (HSCs) but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner.
Journal ArticleDOI
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Kana Miyamoto,Kiyomi Y. Araki,Kazuhito Naka,Fumio Arai,Keiyo Takubo,Satoshi Yamazaki,Sahoko Matsuoka,Takeshi Miyamoto,Keisuke Ito,Masako Ohmura,Chen Chen,Kentaro Hosokawa,Hiromitsu Nakauchi,Keiko Nakayama,Keiichi I. Nakayama,Mine Harada,Noboru Motoyama,Toshio Suda,Atsushi Hirao +18 more
TL;DR: It is demonstrated that Foxo3a, a forkhead transcription factor that acts downstream of the PTEN/PI3K/Akt pathway, is critical for HSC self-renewal and plays a pivotal role in maintaining the HSC pool.
Journal ArticleDOI
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
Hiroki Yoshihara,Fumio Arai,Kentaro Hosokawa,Tetsuya Hagiwara,Keiyo Takubo,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Sahoko Matsuoka,Kana Miyamoto,Hiroshi Miyazaki,Takao Takahashi,Toshio Suda +12 more
TL;DR: It is shown that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, MPL, are a quiescent population in adult bone marrow and are closely associated with THPO-producing osteoblastic cells, suggesting that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastics niche.
Journal ArticleDOI
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70.
Peng Zou,Hiroki Yoshihara,Kentaro Hosokawa,Ikue Tai,Kaori Shinmyozu,Fujiko Tsukahara,Yoshiro Maru,Keiko Nakayama,Keiichi I. Nakayama,Toshio Suda +9 more
TL;DR: It is found that heat shock cognate protein 70 (Hsc70) interacts with both p57 and p27 and that the subcellular localization of Hsc70 was critical to maintain HSC cell cycle kinetics.