K
Kana Miyamoto
Researcher at Keio University
Publications - 63
Citations - 6064
Kana Miyamoto is an academic researcher from Keio University. The author has contributed to research in topics: Osteoclast & Osteoporosis. The author has an hindex of 26, co-authored 56 publications receiving 5401 citations. Previous affiliations of Kana Miyamoto include Toho University & Kumamoto University.
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Journal ArticleDOI
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
Journal ArticleDOI
DC-STAMP is essential for cell–cell fusion in osteoclasts and foreign body giant cells
Mitsuru Yagi,Takeshi Miyamoto,Yumi Sawatani,Katsuya Iwamoto,Naobumi Hosogane,Nobuyuki Fujita,Kozo Morita,Ken Ninomiya,Toru Suzuki,Kana Miyamoto,Yuichi Oike,Motohiro Takeya,Yoshiaki Toyama,Toshio Suda +13 more
TL;DR: An essential regulator of osteoclast and macrophage cell fusion, DC-STAMP, is identified and an essential role of osteOClast multinucleation in bone homeostasis is identified.
Journal ArticleDOI
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Kana Miyamoto,Kiyomi Y. Araki,Kazuhito Naka,Fumio Arai,Keiyo Takubo,Satoshi Yamazaki,Sahoko Matsuoka,Takeshi Miyamoto,Keisuke Ito,Masako Ohmura,Chen Chen,Kentaro Hosokawa,Hiromitsu Nakauchi,Keiko Nakayama,Keiichi I. Nakayama,Mine Harada,Noboru Motoyama,Toshio Suda,Atsushi Hirao +18 more
TL;DR: It is demonstrated that Foxo3a, a forkhead transcription factor that acts downstream of the PTEN/PI3K/Akt pathway, is critical for HSC self-renewal and plays a pivotal role in maintaining the HSC pool.
Journal ArticleDOI
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
Hiroki Yoshihara,Fumio Arai,Kentaro Hosokawa,Tetsuya Hagiwara,Keiyo Takubo,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Sahoko Matsuoka,Kana Miyamoto,Hiroshi Miyazaki,Takao Takahashi,Toshio Suda +12 more
TL;DR: It is shown that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, MPL, are a quiescent population in adult bone marrow and are closely associated with THPO-producing osteoblastic cells, suggesting that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastics niche.
Journal ArticleDOI
Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification
Kozo Morita,Takeshi Miyamoto,Nobuyuki Fujita,Yoshiaki Kubota,Keisuke Ito,Keiyo Takubo,Kana Miyamoto,Ken Ninomiya,Toru Suzuki,Ryotaro Iwasaki,Mitsuru Yagi,Hironari Takaishi,Yoshiaki Toyama,Toshio Suda +13 more
TL;DR: Findings indicate that ROS levels regulate inhibition of proliferation and modulate initiation of the hypertrophic changes in chondrocytes, which is crucial for the longitudinal growth and development of long bones.