S
Sahoko Matsuoka
Researcher at National Institutes of Health
Publications - 29
Citations - 7037
Sahoko Matsuoka is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 14, co-authored 28 publications receiving 6614 citations. Previous affiliations of Sahoko Matsuoka include Keio University.
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Journal ArticleDOI
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Fumio Arai,Atsushi Hirao,Masako Ohmura,Hidetaka Sato,Sahoko Matsuoka,Keiyo Takubo,Keisuke Ito,Gou Young Koh,Toshio Suda +8 more
TL;DR: It is demonstrated that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of H SCs, which adhere to osteoblasts (OBs) in the BM niche.
Journal ArticleDOI
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
Journal ArticleDOI
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito,Atsushi Hirao,Fumio Arai,Sahoko Matsuoka,Keiyo Takubo,Isao Hamaguchi,Kana Nomiyama,Kentaro Hosokawa,Kazuhiro Sakurada,Naomi Nakagata,Yasuo Ikeda,Tak W. Mak,Toshio Suda +12 more
TL;DR: It is shown that ATM has an essential function in the reconstitutive capacity of haematopoietic stem cells (HSCs) but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner.
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Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Kana Miyamoto,Kiyomi Y. Araki,Kazuhito Naka,Fumio Arai,Keiyo Takubo,Satoshi Yamazaki,Sahoko Matsuoka,Takeshi Miyamoto,Keisuke Ito,Masako Ohmura,Chen Chen,Kentaro Hosokawa,Hiromitsu Nakauchi,Keiko Nakayama,Keiichi I. Nakayama,Mine Harada,Noboru Motoyama,Toshio Suda,Atsushi Hirao +18 more
TL;DR: It is demonstrated that Foxo3a, a forkhead transcription factor that acts downstream of the PTEN/PI3K/Akt pathway, is critical for HSC self-renewal and plays a pivotal role in maintaining the HSC pool.
Journal ArticleDOI
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
Hiroki Yoshihara,Fumio Arai,Kentaro Hosokawa,Tetsuya Hagiwara,Keiyo Takubo,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Sahoko Matsuoka,Kana Miyamoto,Hiroshi Miyazaki,Takao Takahashi,Toshio Suda +12 more
TL;DR: It is shown that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, MPL, are a quiescent population in adult bone marrow and are closely associated with THPO-producing osteoblastic cells, suggesting that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastics niche.