K
Kevin J. Kunstman
Researcher at Northwestern University
Publications - 62
Citations - 12037
Kevin J. Kunstman is an academic researcher from Northwestern University. The author has contributed to research in topics: Virus & Simian immunodeficiency virus. The author has an hindex of 44, co-authored 61 publications receiving 11737 citations. Previous affiliations of Kevin J. Kunstman include Harvard University & Johns Hopkins University.
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Journal ArticleDOI
The role of a mutant CCR5 allele in HIV–1 transmission and disease progression
Yaoxing Huang,William A. Paxton,Steven M. Wolinsky,Avidan U. Neumann,Linqi Zhang,Tian He,Stanley Kang,Daniel Ceradini,Zhanqun Jin,Karina Yazdanbakhsh,Kevin J. Kunstman,Daniel L Erickson,Elizabeth A. Dragon,Nathaniel R. Landau,John P. Phair,David D. Ho,Richard A. Koup +16 more
TL;DR: The CCR5 genotype of 1252 homosexual men enrolled in the Chicago component of the Multicenter AIDS Cohort Study (MACS) was analyzed and no evidence was found to suggest that heterozygotes were protected against HIV–1 infection, but a limited protective role against disease progression was noted.
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HIV preferentially infects HIV-specific CD4 + T cells
Daniel C. Douek,Jason M. Brenchley,Michael R. Betts,David R. Ambrozak,Brenna J. Hill,Yukari Okamoto,Joseph P. Casazza,Janaki Kuruppu,Kevin J. Kunstman,Steven M. Wolinsky,Zvi Grossman,Zvi Grossman,Mark Dybul,Annette Oxenius,David Price,Mark Connors,Richard A. Koup +16 more
TL;DR: The findings show that HIV-specific CD4+ T cells are preferentially infected by HIV in vivo, which provides a potential mechanism to explain the loss of HIV- specific CD4- T-cell responses, and consequently theloss of immunological control of HIV replication.
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Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia.
Todd M. Allen,David H. O’Connor,Peicheng Jing,John L. Dzuris,Bianca R. Mothé,Thorsten U. Vogel,Ed Dunphy,Max E. Liebl,Carol Emerson,Nancy A. Wilson,Kevin J. Kunstman,Xiaochi Wang,David B. Allison,Austin L. Hughes,Ronald C. Desrosiers,John D. Altman,Steven M. Wolinsky,Alessandro Sette,David I. Watkins +18 more
TL;DR: It is shown that Tat-specific CD8-positive T-lymphocyte responses select for new viral escape variants during the acute phase of infection, and suggests that responses against viral proteins that are expressed early during the viral life cycle might be attractive targets for HIV vaccine development.
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Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
Manohar R. Furtado,Duncan S. Callaway,John P. Phair,Kevin J. Kunstman,Jennifer Stanton,Catherine A. Macken,Alan S. Perelson,Steven M. Wolinsky +7 more
TL;DR: Unless the quasi-steady state levels of HIV DNA and mRNA eventually disappear with longer periods of therapy, these findings suggest that HIV-1 infection cannot be eradicated with current treatments.
Journal ArticleDOI
Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
Michael Worobey,Marlea Gemmel,Dirk E. Teuwen,Tamara S. Haselkorn,Kevin J. Kunstman,Michael Bunce,Jean Jacques Muyembe,Jean Marie M. Kabongo,Raphael M. Kalengayi,Eric Van Marck,M. Thomas P. Gilbert,M. Thomas P. Gilbert,Steven M. Wolinsky +12 more
TL;DR: The recovery of viral gene sequences from decades-old paraffin-embedded tissues opens the door to a detailed palaeovirological investigation of the evolutionary history of HIV-1 that is not accessible by other methods.