K
Kevin J. McHugh
Researcher at Rice University
Publications - 51
Citations - 1748
Kevin J. McHugh is an academic researcher from Rice University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 16, co-authored 39 publications receiving 1033 citations. Previous affiliations of Kevin J. McHugh include Charles Stark Draper Laboratory & Case Western Reserve University.
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Journal ArticleDOI
Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome
TL;DR: A layer-by-layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines, translating to significantly enhanced survival of LbL-probiotics in vivo.
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The topographical effect of electrospun nanofibrous scaffolds on the in vivo and in vitro foreign body reaction
TL;DR: Results indicate that aligned electrospun nanofibers may serve as a promising scaffold for tissue engineering by minimizing host response, enhancing tissue-scaffold integration, and eliciting a thinner fibrous capsule.
Journal ArticleDOI
Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents.
Kevin J. McHugh,Lihong Jing,Lihong Jing,Adam M. Behrens,Surangi Jayawardena,Wen Tang,Mingyuan Gao,Robert Langer,Ana Jaklenec +8 more
TL;DR: In this article, state-of-the-art biocompatible QDs are compared with current FDA and Drug Administration approved fluorophores used in cancer imaging and a perspective on the pathway to clinical translation is provided.
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Fabrication of fillable microparticles and other complex 3D microstructures
Kevin J. McHugh,Thanh D. Nguyen,Allison R. Linehan,David Y. Yang,Adam M. Behrens,Sviatlana Rose,Zachary L. Tochka,Stephany Y. Tzeng,James J. Norman,Aaron C. Anselmo,Xian Xu,Stephanie Tomasic,Matthew A. Taylor,Jennifer Lu,Rohiverth Guarecuco,Robert Langer,Ana Jaklenec +16 more
TL;DR: A microfabrication method is described, termed StampEd Assembly of polymer Layers (SEAL), and injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that the authors could not produce using traditional 3D printing are created.
Journal ArticleDOI
Engineered PLGA microparticles for long-term, pulsatile release of STING agonist for cancer immunotherapy.
Xueguang Lu,Lei Miao,Wenting Gao,Ziqi Chen,Kevin J. McHugh,Kevin J. McHugh,Yehui Sun,Zachary L. Tochka,Stephanie Tomasic,Kaitlyn Sadtler,Kaitlyn Sadtler,Alain Hyacinthe,Yuxuan Huang,Tyler Graf,Quanyin Hu,Morteza Sarmadi,Robert Langer,Daniel G. Anderson,Ana Jaklenec +18 more
TL;DR: A single intratumoral injection of STING agonist–loaded microparticles triggered potent local and systemic antitumor immune responses, inhibited tumor growth, and prolonged survival as effectively as multiple soluble doses, but with reduced metastasis in several mouse tumor models.