K
Kevin K. Kumar
Researcher at Stanford University
Publications - 26
Citations - 664
Kevin K. Kumar is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Neurodegeneration. The author has an hindex of 12, co-authored 23 publications receiving 493 citations. Previous affiliations of Kevin K. Kumar include Vanderbilt University & Allen Institute for Brain Science.
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Journal ArticleDOI
Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression
Maria H. Milekic,Yurong Xin,Anne H. O'Donnell,Kevin K. Kumar,M Bradley-Moore,Dolores Malaspina,Holly Moore,Daniela Brunner,Yongchao Ge,John R. Edwards,Stéphane Paul,Fatemeh Haghighi,Jay A. Gingrich +12 more
TL;DR: It is demonstrated that DNA methylation abnormalities arising in the sperm of old fathers are a plausible mechanism to explain some of the risks that APA poses to resulting offspring.
Journal ArticleDOI
Cellular manganese content is developmentally regulated in human dopaminergic neurons
Kevin K. Kumar,Edward W. Lowe,Asad A. Aboud,M. Diana Neely,Rey Redha,Joshua A. Bauer,Mihir Odak,C. David Weaver,Jens Meiler,Michael Aschner,Aaron B. Bowman +10 more
TL;DR: This work demonstrates cell-level regulation of Mn content across neuronal differentiation, and reports differential Mn accumulation between developmental stages and stage-specific differences in the Mn-altering activity of individual small molecules.
Journal ArticleDOI
A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease
Andrew M. Tidball,Miles R. Bryan,Michael A. Uhouse,Kevin K. Kumar,Asad A. Aboud,Jack E. Feist,Kevin C. Ess,M. Diana Neely,Michael Aschner,Aaron B. Bowman +9 more
TL;DR: Analysis of ATM autophosphorylation and additional ATM kinase targets, H2AX and CHK2, support a role for ATM in the activation of p53 by manganese and that a defect in this process occurs in HD.
Journal ArticleDOI
PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper
Asad A. Aboud,Andrew M. Tidball,Kevin K. Kumar,M. Diana Neely,Bingying Han,Kevin C. Ess,Charles C. Hong,Keith M. Erikson,Peter Hedera,Aaron B. Bowman +9 more
TL;DR: The data substantiate Cu exposure as an environmental risk factor for PD and report a shift in the lowest observable effect level (LOEL) for greater sensitivity to Cu-dependent mitochondrial dysfunction in patients SM and PM relative to controls, correlating with their increased genetic risk for PD.
Journal ArticleDOI
Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.
Asad A. Aboud,Andrew M. Tidball,Kevin K. Kumar,M. Diana Neely,Kevin C. Ess,Keith M. Erikson,Aaron B. Bowman +6 more
TL;DR: This report offers the first example of human subject-specific differences in PD-relevant environmental health related phenotypes that are consistent with pathogenic interactions between known genetic and environmental risk factors for PD.