Kevin Rostasy

TL;DR: Revised criteria are proposed for pediatric acute disseminated encephalomyelitis, pediatric clinically isolated syndrome, pediatric neuromyELitis optica and pediatric MS to incorporate advances in delineating the clinical and neuroradiologic features of these disorders.

TL;DR: In this article, high-titer autoantibodies to human native MOG were detected in a subgroup of pediatric acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) patients and seven of 21 (33%) AQP4-IgG negative HR-NMO patients.

TL;DR: It is indicated that thrombophilias serve as risk factors for incident stroke through a meta-analysis of published observational studies and no significant heterogeneity was discerned across studies, and no publication bias was detected.

TL;DR: The analysis defines the phenotypic spectrum of AGS and suggests a coherent mutation-screening strategy in this heterogeneous disorder, and indicates that at least one further AGS-causing gene remains to be identified.

TL;DR: Cell-based immunoassays using MOG expressed in mammalian cells have demonstrated the presence of high-titre MOG antibodies in paediatric patients with acute disseminated encephalomyelitis, MS, aquaporin-4-seronegative neuromyELitis optica, or isolated optic neuritis or transverse myelitis; these studies indicate that Mog antibodies could be associated with a broad spectrum of acquired human CNS demyelinating diseases.