K
Khanh Huy Bui
Researcher at McGill University
Publications - 59
Citations - 4308
Khanh Huy Bui is an academic researcher from McGill University. The author has contributed to research in topics: Microtubule & Axoneme. The author has an hindex of 25, co-authored 50 publications receiving 3073 citations. Previous affiliations of Khanh Huy Bui include Paul Scherrer Institute & European Bioinformatics Institute.
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Journal ArticleDOI
The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications.
Ahmad Abdelzaher Zaki Khalifa,Muneyoshi Ichikawa,Daniel Dai,Shintaroh Kubo,Shintaroh Kubo,Corbin Black,Katya Peri,Thomas S. McAlear,Simon Veyron,Shun Kai Yang,Javier Vargas,Susanne Bechstedt,Jean-François Trempe,Khanh Huy Bui +13 more
TL;DR: The structural study of the doublets of Chlamydomonas reinhardtii and Tetrahymena thermophila shows that the inner junction serves as an interaction hub that involves tubulin post-translational modifications that contribute to the stability of thedoublet and hence, normal ciliary motility.
Journal ArticleDOI
In situ structural analysis of the human nuclear pore complex
Alexander von Appen,Jan Kosinski,Lenore Sparks,Alessandro Ori,Amanda L. DiGuilio,Benjamin Vollmer,Marie-Therese Mackmull,Niccolò Banterle,Luca Parca,Panagiotis L. Kastritis,Katarzyna Buczak,Shyamal Mosalaganti,Wim J. H. Hagen,Amparo Andres-Pons,Edward A. Lemke,Peer Bork,Wolfram Antonin,Joseph S. Glavy,Khanh Huy Bui,Martin Beck +19 more
TL;DR: This work combines cryo-electron tomography with mass spectrometry, biochemical analysis, perturbation experiments and structural modelling to generate the most comprehensive architectural model of the human nuclear pore complex to date.
Journal ArticleDOI
Integrated Structural Analysis of the Human Nuclear Pore Complex Scaffold
Khanh Huy Bui,Alexander von Appen,Amanda L. DiGuilio,Alessandro Ori,Lenore Sparks,Marie-Therese Mackmull,Thomas Bock,Wim J. H. Hagen,Amparo Andres-Pons,Joseph S. Glavy,Martin Beck +10 more
TL;DR: It is shown that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the NPC, which may explain how changes of the diameter are realized that would accommodate transport of huge cargoes.
Journal ArticleDOI
Fourier ring correlation as a resolution criterion for super-resolution microscopy.
TL;DR: It is shown that Fourier ring correlation provides an easy-to-use, laboratory consistent standard for measuring the resolution of SRM images, and is provided a freely available software tool that combines resolution measurement with image reconstruction.
Journal ArticleDOI
Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Jan Kosinski,Shyamal Mosalaganti,Alexander von Appen,Roman Teimer,Amanda L. DiGuilio,William Wan,Khanh Huy Bui,Wim J. H. Hagen,John A. G. Briggs,Joseph S. Glavy,Ed Hurt,Martin Beck +11 more
TL;DR: This architectural map explains the vast majority of the electron density of the scaffold, and concludes that despite obvious differences in morphology and composition, the higher-order structure of the inner and outer rings is unexpectedly similar.