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Amanda L. DiGuilio
Researcher at Stevens Institute of Technology
Publications - 9
Citations - 977
Amanda L. DiGuilio is an academic researcher from Stevens Institute of Technology. The author has contributed to research in topics: Nuclear pore & Nucleoporin. The author has an hindex of 6, co-authored 8 publications receiving 815 citations. Previous affiliations of Amanda L. DiGuilio include University of Chicago.
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Journal ArticleDOI
In situ structural analysis of the human nuclear pore complex
Alexander von Appen,Jan Kosinski,Lenore Sparks,Alessandro Ori,Amanda L. DiGuilio,Benjamin Vollmer,Marie-Therese Mackmull,Niccolò Banterle,Luca Parca,Panagiotis L. Kastritis,Katarzyna Buczak,Shyamal Mosalaganti,Wim J. H. Hagen,Amparo Andres-Pons,Edward A. Lemke,Peer Bork,Wolfram Antonin,Joseph S. Glavy,Khanh Huy Bui,Martin Beck +19 more
TL;DR: This work combines cryo-electron tomography with mass spectrometry, biochemical analysis, perturbation experiments and structural modelling to generate the most comprehensive architectural model of the human nuclear pore complex to date.
Journal ArticleDOI
Integrated Structural Analysis of the Human Nuclear Pore Complex Scaffold
Khanh Huy Bui,Alexander von Appen,Amanda L. DiGuilio,Alessandro Ori,Lenore Sparks,Marie-Therese Mackmull,Thomas Bock,Wim J. H. Hagen,Amparo Andres-Pons,Joseph S. Glavy,Martin Beck +10 more
TL;DR: It is shown that 32 copies of the Nup107 subcomplex assemble into two reticulated rings, one each at the cytoplasmic and nuclear face of the NPC, which may explain how changes of the diameter are realized that would accommodate transport of huge cargoes.
Journal ArticleDOI
Molecular architecture of the inner ring scaffold of the human nuclear pore complex.
Jan Kosinski,Shyamal Mosalaganti,Alexander von Appen,Roman Teimer,Amanda L. DiGuilio,William Wan,Khanh Huy Bui,Wim J. H. Hagen,John A. G. Briggs,Joseph S. Glavy,Ed Hurt,Martin Beck +11 more
TL;DR: This architectural map explains the vast majority of the electron density of the scaffold, and concludes that despite obvious differences in morphology and composition, the higher-order structure of the inner and outer rings is unexpectedly similar.
Journal ArticleDOI
Nucleoporin Nup155 is part of the p53 network in liver cancer.
Kerstin Holzer,Kerstin Holzer,Alessandro Ori,Amy Cooke,Daniel Dauch,Elisabeth Drucker,Philip Riemenschneider,Amparo Andres-Pons,Amanda L. DiGuilio,Amanda L. DiGuilio,Marie-Therese Mackmull,Jochen Baßler,Stephanie Roessler,Kai Breuhahn,Lars Zender,Joseph S. Glavy,Joseph S. Glavy,Frank Dombrowski,Ed Hurt,Peter Schirmacher,Martin Beck,Stephan Singer,Stephan Singer +22 more
TL;DR: It is shown that Nup155 from the NPC inner ring regulates the p53 pathway by controlling p21 translation while also being a target of p53-mediated repression.
Journal ArticleDOI
Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).
Juliane Winkler,Stephanie Roessler,Carsten Sticht,Amanda L. DiGuilio,Elisabeth Drucker,Kerstin Holzer,E Eiteneuer,Esther Herpel,Kai Breuhahn,Norbert Gretz,Peter Schirmacher,Alessandro Ori,Stephan Singer,Stephan Singer +13 more
TL;DR: The data suggest a previously unanticipated link between CAS and integrin signaling which correlates with an aggressive HCC phenotype, and the potential in vivo relevance of CAS.