Khaoula Belhaj

TL;DR: It is shown that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation and depletes the autophagic cargo receptor Joka2 out of ATG 8CL complexes and interferes with Joka1's positive effect on pathogen defense.

TL;DR: This work shows that during infection, ATG8CL/Joka2 labelled defense-related autophagosomes are diverted toward the perimicrobial host membrane to restrict pathogen growth, and shows that the host-pathogen interface is a hotspot for autophagy biogenesis.

TL;DR: A comprehensive protein–protein interaction resource is described, obtained using in planta immunoprecipitation followed by mass spectrometry (MS), to define the potato ATG8 interactome, and findings are consistent with the view that ATg8 isoforms comprise a layer of specificity in the regulation of selective autophagy pathways in plants.

TL;DR: This work has revealed that two species of Albugo upregulate genes associated with tryptophan-derived antimicrobial metabolites in Arabidopsis and contribute to suppression of non-host resistance to P. infestans.

TL;DR: A comprehensive protein-protein interaction resource is described, obtained using in planta immunoprecipitation followed by mass spectrometry, to define the potato ATG8 interactome, and it is found that the N-terminal β-strand—and, in particular, a single amino acid polymorphism—underpins binding specificity to the substrate PexRD54 by shaping the hydrophobic pocket that accommodates this protein’s AtG8 interacting motif.