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Bhagirath Chaurasia
Researcher at Baker IDI Heart and Diabetes Institute
Publications - 13
Citations - 1701
Bhagirath Chaurasia is an academic researcher from Baker IDI Heart and Diabetes Institute. The author has contributed to research in topics: Adipose tissue & Insulin resistance. The author has an hindex of 10, co-authored 10 publications receiving 1378 citations. Previous affiliations of Bhagirath Chaurasia include University of Cologne & Max Planck Society.
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Journal ArticleDOI
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Jan Mauer,Bhagirath Chaurasia,Julia Goldau,Merly C. Vogt,Johan Ruud,Khoa D. Nguyen,Sebastian Theurich,A. Christine Hausen,Joel Schmitz,Hella S. Brönneke,Emma Estevez,Tamara L Allen,Andrea Mesaros,Linda Partridge,Mark A. Febbraio,Ajay Chawla,F. Thomas Wunderlich,Jens C. Brüning +17 more
TL;DR: The results identify signaling via IL-6 as an important determinant of the alternative activation of macrophages and assign an unexpected homeostatic role to IL- 6 in limiting inflammation.
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Ceramides – Lipotoxic Inducers of Metabolic Disorders
TL;DR: The need to further decipher the full array of benefits elicited by ceramide depletion is highlighted, suggesting that inhibiting ceramide biosynthesis or catalyzing ceramide degradation in rodents ameliorates many metabolic disorders including diabetes, cardiomyopathy, insulin resistance, atherosclerosis, and steatohepatitis.
Journal ArticleDOI
Adipocyte Ceramides Regulate Subcutaneous Adipose Browning, Inflammation, and Metabolism.
Bhagirath Chaurasia,Vincent A. Kaddai,Graeme I. Lancaster,Darren C. Henstridge,Sandhya Sriram,Dwight L. A. Galam,Venkatesh Gopalan,K. N. Bhanu Prakash,S. Sendhil Velan,Sarada Bulchand,Teh Jing Tsong,Mei Wang,Monowarul Mobin Siddique,Guan Yuguang,Kristmundur Sigmundsson,Natalie A. Mellet,Jacquelyn M. Weir,Peter J. Meikle,M. Shabeer Yassin,Asim Shabbir,James A. Shayman,Yoshio Hirabayashi,Sue Anne Toh Ee Shiow,Shigeki Sugii,Scott A. Summers +24 more
TL;DR: It is demonstrated that subcutaneous adipose tissue of type 2 diabetics contains considerably more sphingolipids than non-diabetic, BMI-matched counterparts and that newly synthesized adipocyte sphingoipids are nutrient signals that drive changes in the adipose phenotype to influence whole-body energy expenditure and nutrient metabolism.
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Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity
Alexander Jais,Alexander Jais,Maite Solas,Maite Solas,Heiko Backes,Bhagirath Chaurasia,André Kleinridders,Sebastian Theurich,Sebastian Theurich,Jan Mauer,Jan Mauer,Sophie M. Steculorum,Sophie M. Steculorum,Brigitte Hampel,Brigitte Hampel,Julia Goldau,Julia Goldau,Jens Alber,Jens Alber,Carola Förster,Sabine A. Eming,Markus Schwaninger,Napoleone Ferrara,Gerard Karsenty,Jens C. Brüning +24 more
TL;DR: The experiments reveal that transient, HFD-elicited reduction of brain glucose uptake initiates a compensatory increase of VEGF production and assign obesity-associated macrophage activation a homeostatic role to restore cerebral glucose metabolism, preserve cognitive function, and limit neurodegeneration in obesity.
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Dihydroceramides: From Bit Players to Lead Actors
TL;DR: This minireview summarizes recent findings on this emerging class of bioactive lipids and suggests that these dihydroceramides accumulate to a far greater extent in tissues than previously thought.