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Nancy A. O'Rourke
Researcher at Stanford University
Publications - 32
Citations - 5411
Nancy A. O'Rourke is an academic researcher from Stanford University. The author has contributed to research in topics: Cerebral cortex & Tomography. The author has an hindex of 21, co-authored 32 publications receiving 4641 citations. Previous affiliations of Nancy A. O'Rourke include California Institute of Technology & University of California, Irvine.
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Journal ArticleDOI
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Anca M. Pasca,Steven A. Sloan,Laura E. Clarke,Yuan Tian,Christopher D. Makinson,Nina Huber,Chul Hoon Kim,Jin-Young Park,Nancy A. O'Rourke,Khoa D. Nguyen,Stephen J. Smith,John R. Huguenard,Daniel H. Geschwind,Ben A. Barres,Sergiu P. Paşca +14 more
TL;DR: A simple and reproducible 3D culture approach for generating a laminated cerebral cortex–like structure, named human cortical spheroids (hCSs), from pluripotent stem cells, which demonstrate that cortical neurons participate in network activity and produce complex synaptic events.
Journal ArticleDOI
Assembly of functionally integrated human forebrain spheroids
Fikri Birey,Jimena Andersen,Christopher D. Makinson,Saiful Islam,Wu Wei,Nina Huber,H. Christina Fan,Kimberly R. Cordes Metzler,Georgia Panagiotakos,Nicholas Thom,Nancy A. O'Rourke,Lars M. Steinmetz,Lars M. Steinmetz,Jonathan A. Bernstein,Joachim Hallmayer,John R. Huguenard,Sergiu P. Paşca +16 more
TL;DR: Three-dimensional spheroids from human pluripotent stem cells that resemble either the dorsal or ventral forebrain and contain cortical glutamatergic or GABAergic neurons are generated and it is found that in Timothy syndrome—a neurodevelopmental disorder caused by mutations in the CaV1.2 calcium channel—interneurons display abnormal migratory saltations.
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Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Cagla Eroglu,Cagla Eroglu,Nicola J. Allen,Michael W. Susman,Nancy A. O'Rourke,Chan Young Park,Engin Özkan,Chandrani Chakraborty,Sara B. Mulinyawe,Douglas S. Annis,Andrew D. Huberman,Eric M. Green,Jack Lawler,Ricardo E. Dolmetsch,K. Christopher Garcia,Stephen J. Smith,Z. David Luo,Arnon Rosenthal,Deane F. Mosher,Ben A. Barres +19 more
TL;DR: The neuronal thrombospondin receptor involved in CNS synapse formation is identified as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin and suggested that gapapentin may function therapeutically by blocking new synapses formation.
Journal ArticleDOI
Diverse migratory pathways in the developing cerebral cortex.
TL;DR: Time-lapse confocal microscopy was used to observe directly the dynamic behaviors of migrating cells in living slices of developing cortex, and the majority of cells migrated along a radial pathway, consistent with the view that cortical neurons migrate along radial glial fibers.
Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Cagla Eroglu,Nicola J. Allen,Michael W. Susman,Nancy A. O'Rourke,Chan Young Park,Engin Oezkan,Chandrani Chakraborty,Sara B. Mulinyawe,Douglas S. Annis,Andrew D. Huberman,Eric M. Green,Jack Lawler,Ricardo E. Dolmetsch,K. Christopher Garcia,Stephen J. Smith,Z. David Luo,Arnon Rosenthal,Deane F. Mosher,Ben A. Barres +18 more