Ki Yun Kim

TL;DR: Results demonstrate that kaempferol-mediated antitumor activity toward Jurkat T cells was attributable to G2-checkpoint activation, which caused not only G1-arrest of the cell cycle but also activating phosphorylation of p53 (Ser-15) and subsequent induction of mitochondriadependent apoptotic events, including Bak and PUMA upregulation, Bak activation, Δpsim loss, and caspase cascade activation.

TL;DR: It is demonstrated that l-serine can protect neuronal cells against oxidative stress-mediated apoptotic cell death by contributing to intracellular antioxidant GSH synthesis and maintaining the mitochondrial fusion-fission balance.

TL;DR: Cotreatment with the autophagy inhibitor resulted in a significant enhancement of quercetin-induced BAK activation and subsequently the mitochondrial damage-mediated apoptosis pathway by augmenting the downregulation of BAG3 and MCL-1 levels in J/Neo cells.

TL;DR: In this paper, seven phenolic compounds including p-coumaric acid, 4-hydroxybenzoic acid and vanillic acid were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains.

TL;DR: Results indicate that MiTMAB-caused cytokinesis failure leads to concomitant induction of apoptosis and cytoprotective autophagy, and suggest that inhibition of autophagic responses is a promising strategy to augment antitumor activity of MiT MAB.